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Total Synuclein-γ Cell-Based Colorimetric ELISA Kit

-KA3386C

Catalog: KA3386C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
SNCG
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Other Name:
Gamma-synuclein ;
Breast cancer-specific gene 1 protein ;
Persyn ;
Synoretin ;
SR ;
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Database Link:
Organism Gene ID SwissProt
Human 6623; O76070;
Mouse Q9Z0F7;
Background:
disease:Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions.,function:Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway.,PTM:Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.,similarity:Belongs to the synuclein family.,subcellular location:Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.,subunit:May be a centrosome-associated protein.,tissue specificity:Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.,
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Function:
behavior, locomotory behavior, adult locomotory behavior, regulation of dopamine secretion, adult behavior,regulation of neurological system process, regulation of system process, regulation of neurotransmitter secretion,regulation of catecholamine secretion, regulation of synaptic transmission, regulation of secretion, regulation of neurotransmitter transport, regulation of amine transport, regulation of transmission of nerve impulse, regulation of cellular localization,
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Cellular Localization:
Cytoplasm, perinuclear region . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle . Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
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Tissue Expression:
Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
show all
Catalog: KA3386C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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