SNAP25

Synaptosomal-associated protein 25 ;
SNAP-25 ;
Super protein ;
SUP ;
Synaptosomal-associated 25 kDa protein ;

alternative products:Isoforms differ by the usage of two alternative homologous exons (5a and 5b) which encode for positions 56 to 94 and differ only in 9 positions out of 39,function:t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.,miscellaneous:When cloned and expressed in Eschericia coli, where protein palmitoylation does not occur, Cys-85, Cys-88, Cys-90 and Cys-92 in the protein sequence readily form an iron-sulfur cluster instead.,PTM:Palmitoylated. Cys-85 appears to be the main site, and palmitoylation is required for membrane association.,similarity:Belongs to the SNAP-25 family.,similarity:Contains 2 t-SNARE coiled-coil homology domains.,subcellular location:Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region.,subunit:Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with CENPF, TRIM9, RIMS1, SNAP25BP, OTOF and HGS. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Found in a complex containing SYT1, SV2B and syntaxin-1.,tissue specificity:Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.,

cell morphogenesis, cell morphogenesis involved in differentiation, neurotransmitter uptake, regulation of neurotransmitter levels, peptide secretion, regulation of peptide secretion, positive regulation of peptide secretion,generation of a signal involved in cell-cell signaling, neurotransmitter transport, exocytosis, vesicle docking during exocytosis, cell-cell signaling, synaptic transmission, neurotransmitter secretion, axonogenesis, behavior, learning or memory, memory, long-term memory, hormone transport, regulation of hormone levels, peptide transport, synaptic vesicle exocytosis, synaptic vesicle docking during exocytosis, vesicle-mediated transport, endosome transport,transmission of nerve impulse, membrane docking, cell projection organization, peptide hormone secretion, neuron differentiation, growth hormone secretion, sleep, neuron projection development, positive regulation of insulin secretion, secretion by cell, cellular component morphogenesis, cell part morphogenesis, regulation of cellular component biogenesis, hormone secretion, regulation of hormone secretion, positive regulation of hormone secretion,secretion, intracellular transport, vesicle docking, synaptic vesicle transport, neuron development, cell morphogenesis involved in neuron differentiation, calcium ion-dependent exocytosis of neurotransmitter, neuron projection morphogenesis, cell projection morphogenesis, regulation of insulin secretion, regulation of synapse structure and activity, regulation of synapse organization, neurological system process, cognition, regulation of secretion, positive regulation of secretion, positive regulation of transport, regulation of nervous system development, regulation of synaptogenesis, regulation of cellular localization,

Cytoplasm, perinuclear region . Cell membrane ; Lipid-anchor . Cell junction, synapse, synaptosome . Photoreceptor inner segment . Membrane association requires palmitoylation. Expressed throughout cytoplasm, concentrating at the perinuclear region. Colocalizes with KCNB1 at the cell membrane (By similarity). Colocalizes with PLCL1 at the cell membrane (By similarity). .

Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum.