RAN

GTP-binding nuclear protein Ran ;
Androgen receptor-associated protein 24 ;
GTPase Ran ;
Ras-like protein TC4 ;
Ras-related nuclear protein ;

function:Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.,function:GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.,PTM:The N-terminus is blocked.,similarity:Belongs to the small GTPase superfamily. Ran family.,subcellular location:Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Monomer. Also forms a complex with CHC1 and interacts with the AR N-terminal poly-Gln region. The interaction with AR is inversely correlated with the poly-Gln length. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Found in a nuclear export complex with RANBP3 and XPO1. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts with RANBP10. In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) and XPO1. Found in a complex with HTLV-1 Rex, RANBP3 and XPO1.,tissue specificity:Expressed in a variety of tissues.,

M phase of mitotic cell cycle, microtubule cytoskeleton organization, mitotic cell cycle, M phase, nuclear division,reproductive developmental process, DNA metabolic process, regulation of transcription, DNA-dependent, RNA localization, RNA export from nucleus, protein targeting, protein import into nucleus, protein export from nucleus,intracellular protein transport, nucleocytoplasmic transport, cytoskeleton organization, microtubule-based process, cell cycle, spindle organization, mitotic spindle organization, mitosis, intracellular signaling cascade, gamete generation,germ cell development, spermatogenesis, spermatid development, protein localization, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, protein transport, nucleobase, nucleoside, nucleotide and nucleic acid transport, protein import, sexual reproduction, cell cycle process, cell cycle phase, steroid hormone receptor signaling pathway, androgen receptor signaling pathway, intracellular receptor-mediated signaling pathway,positive regulation of cellular biosynthetic process, multicellular organism reproduction, protein localization in organelle, protein localization in nucleus, cellular protein localization, establishment of protein localization, regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, intracellular transport, male gamete generation, organelle fission, spermatid differentiation, reproductive process in a multicellular organism, reproductive cellular process, nucleic acid transport, RNA transport, nuclear export, nuclear transport, nuclear import, positive regulation of nitrogen compound metabolic process, establishment of RNA localization, regulation of RNA metabolic process, positive regulation of RNA metabolic process, cell division, cellular macromolecule localization,

Nucleus . Nucleus envelope . Cytoplasm, cytosol . Cytoplasm . Melanosome . Predominantly nuclear during interphase (PubMed:8421051, PubMed:12194828, PubMed:10679025). Becomes dispersed throughout the cytoplasm during mitosis (PubMed:8421051, PubMed:12194828). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .

Expressed in a variety of tissues.