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Total PCNA Cell-Based Colorimetric ELISA Kit

-KA3356C

Catalog: KA3356C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
PCNA
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Other Name:
Proliferating cell nuclear antigen ;
PCNA ;
Cyclin ;
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Database Link:
Organism Gene ID SwissProt
Human 5111; P12004;
Mouse P17918;
Rat P04961;
Background:
disease:Antibodies are present in sera from patients with systemic lupus erythematosus.,function:This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.,online information:PCNA entry,PTM:Upon methyl methanesulfonate-induced DNA damage, mono-ubiquitinated by the UBE2B-RAD18 complex on Lys-164. This induces non-canonical poly-ubiquitination on Lys-164 through 'Lys-63' linkage of ubiquitin moieties by the E2 complex UBE2N-UBE2V2 and the E3 ligases RNF8 and SHPRH, which are required for DNA repair.,similarity:Belongs to the PCNA family.,subunit:Homotrimer. Interacts with KCTD10. Interacts with PPP1R15A (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with POLH, POLK, DNMT1, ERCC5/XPG, FEN1, CDC6, APEX2 and POLDIP2. Interacts with EXO1 and SHPRH. Forms a ternary complex with DNTTIP2 and core histone. Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B/WSTF; the interaction is direct.,
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Function:
DNA metabolic process, DNA replication, regulation of DNA replication, DNA repair, base-excision repair, base-excision repair, gap-filling, nucleotide-excision repair, nucleotide-excision repair, DNA gap filling, mismatch repair, intracellular protein transport, response to DNA damage stimulus, intracellular signaling cascade, protein localization, cell proliferation, protein transport, second-messenger-mediated signaling, cellular response to stress, cellular protein localization, establishment of protein localization, intracellular transport, phosphoinositide-mediated signaling,regulation of DNA metabolic process, cellular macromolecule localization,
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Cellular Localization:
Nucleus . Colocalizes with CREBBP, EP300 and POLD1 to sites of DNA damage (PubMed:24939902). Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase (PubMed:15543136). Co-localizes with SMARCA5/SNF2H and BAZ1B/WSTF at replication foci during S phase (PubMed:15543136). Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents. .
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Catalog: KA3356C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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