CDKN2C

Cyclin-dependent kinase 4 inhibitor C ;
Cyclin-dependent kinase 6 inhibitor ;
p18-INK4c ;
p18-INK6 ;

disease:Defects in CDKN2C are involved in tumor formation.,function:Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.,similarity:Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.,similarity:Contains 4 ANK repeats.,subunit:Heterodimer of p18 with CDK6.,tissue specificity:Highest levels found in skeletal muscle. Also found in pancreas and heart.,

regulation of cyclin-dependent protein kinase activity, G1/S transition of mitotic cell cycle, mitotic cell cycle, regulation of cell growth, induction of apoptosis, cell cycle, cell cycle arrest, negative regulation of cell proliferation, regulation of cell size, glial cell differentiation, negative regulation of phosphorus metabolic process, regulation of cell death,positive regulation of cell death, induction of programmed cell death, regulation of phosphate metabolic process, cell cycle process, cell cycle phase, negative regulation of cell growth, regulation of cellular component size, regulation of growth, gliogenesis, regulation of cell proliferation, regulation of phosphorylation, negative regulation of phosphorylation, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death,positive regulation of programmed cell death, regulation of kinase activity, negative regulation of cell size, regulation of protein kinase activity, negative regulation of growth, negative regulation of phosphate metabolic process,oligodendrocyte differentiation, regulation of phosphorus metabolic process, interphase, interphase of mitotic cell cycle, regulation of transferase activity, regulation of cell cycle,

Highest levels found in skeletal muscle. Also found in pancreas and heart.