Catalog: KA3332C
Size
Price
Status
Qty.
96well
$330.00
In stock
0
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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KA3332C
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Antigen&Target Information
Gene Name:
MMP3
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Other Name:
Stromelysin-1 ;
SL-1 ;
Matrix metalloproteinase-3 ;
MMP-3 ;
Transin-1 ;
SL-1 ;
Matrix metalloproteinase-3 ;
MMP-3 ;
Transin-1 ;
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Background:
catalytic activity:Preferential cleavage where P1', P2' and P3' are hydrophobic residues.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,function:Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,
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Function:
response to acid, proteolysis, response to endogenous stimulus, response to organic substance, response to organic nitrogen, response to amine stimulus, collagen catabolic process, collagen metabolic process, response to cytokine stimulus, response to amino acid stimulus, multicellular organismal metabolic process, multicellular organismal catabolic process, multicellular organismal macromolecule metabolic process,
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Cellular Localization:
Secreted, extracellular space, extracellular matrix .
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Signaling Pathway
Organismal Systems >> Immune system >> IL-17 signaling pathway
Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer
Human Diseases >> Cancer: specific types >> Prostate cancer
Human Diseases >> Immune disease >> Rheumatoid arthritis
Environmental Information Processing >> Signal transduction >> TNF signaling pathway
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Catalog: KA3332C
Size
Price
Status
Qty.
96well
$330.00
In stock
0
Add to cart
Collected
Collect
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