HSPA5

78 kDa glucose-regulated protein ;
GRP-78 ;
Endoplasmic reticulum lumenal Ca ;
2+ ;
-binding protein grp78 ;
Heat shock 70 kDa protein 5 ;
Immunoglobulin heavy chain-binding protein ;
BiP ;

disease:Autoantigen in rheumatoid arthritis [MIM:180300].,function:Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A.,

anti-apoptosis, ER overload response, ER-nuclear signaling pathway, cellular response to starvation, response to extracellular stimulus, negative regulation of peptidase activity, regulation of cell death, response to nutrient levels,cellular response to extracellular stimulus, cellular response to nutrient levels, cellular response to stress, response to endoplasmic reticulum stress, cellular response to glucose starvation, response to starvation, regulation of apoptosis,negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death,negative regulation of catalytic activity, negative regulation of caspase activity, regulation of caspase activity, negative regulation of molecular function, regulation of hydrolase activity, negative regulation of hydrolase activity, regulation of peptidase activity, regulation of endopeptidase activity, negative regulation of cell death,

Endoplasmic reticulum lumen . Melanosome . Cytoplasm . Cell surface . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). Localizes to the cell surface of epithelial cells in response to high levels of free iron (PubMed:20484814, PubMed:24355926, PubMed:27159390). .