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Total HSP A5 Cell-Based Colorimetric ELISA Kit

-KA3283C

Catalog: KA3283C
Size
Price
Status
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96well
$330.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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KA3283C

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Antigen&Target Information
Gene Name:
HSPA5 GRP78
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Other Name:
78 kDa glucose-regulated protein ;
GRP-78 ;
Endoplasmic reticulum lumenal Ca ;
2+ ;
-binding protein grp78 ;
Heat shock 70 kDa protein 5 ;
Immunoglobulin heavy chain-binding protein ;
BiP ;
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Database Link:
Organism Gene ID SwissProt
Human 3309; P11021;
Mouse 14828; P20029;
Rat P06761;
Background:
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010],
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Function:
Disease:Autoantigen in rheumatoid arthritis [MIM:180300].,Function:Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.,similarity:Belongs to the heat shock protein 70 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Interacts with DNAJC1 (via J domain) (By similarity). Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with TMEM132A.,
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Cellular Localization:
Endoplasmic reticulum lumen . Melanosome . Cytoplasm . Cell surface . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). Localizes to the cell surface of epithelial cells in response to high levels of free iron (PubMed:20484814, PubMed:24355926, PubMed:27159390). .
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Catalog: KA3283C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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