LGALS3

Galectin-3 ;
Gal-3 ;
35 kDa lectin ;
Carbohydrate-binding protein 35 ;
CBP 35 ;
Galactose-specific lectin 3 ;
Galactoside-binding protein ;
GALBP ;
IgE-binding protein ;
L-31 ;
Laminin-binding protein ;
Lectin L-29 ;
Mac-2 antigen ;

function:Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis.,online information:Galectin-3,similarity:Contains 1 galectin domain.,subcellular location:Cytoplasmic in adenomas and carcinomas. May be secreted by a non-classical secretory pathway and associate with the cell surface.,subunit:Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA.,tissue specificity:A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages.,

skeletal system development, extracellular matrix organization, extracellular structure organization,

Cytoplasm . Nucleus. Secreted . Secreted by a non-classical secretory pathway and associates with the cell surface. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .

A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.