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Total FOP Cell-Based Colorimetric ELISA Kit

-KA3257C

Catalog: KA3257C
Size
Price
Status
Qty.
96well
$330.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
FGFR1OP
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Other Name:
FGFR1 oncogene partner
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Database Link:
Organism Gene ID SwissProt
Human 11116; O95684;
Mouse Q66JX5;
Rat Q4V7C1;
Background:
disease:A chromosomal aberration involving FGFR1OP may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.,function:Required for anchoring microtubules to the centrosomes.,similarity:Contains 1 LisH domain.,subcellular location:Associated with gamma-tubulin.,subunit:Homodimer. Part of a ternary complex that contains CEP350, FGFR1OP and MAPRE1. Interacts directly with CEP350 and MAPRE1.,tissue specificity:Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.,
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Function:
microtubule cytoskeleton organization, cytoskeleton organization, microtubule-based process, protein localization,positive regulation of cell proliferation, maintenance of protein location in cell, microtubule anchoring, regulation of cell proliferation, maintenance of protein location, maintenance of location, maintenance of location in cell,
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Cellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Associated with gamma-tubulin (PubMed:16314388). Localizes on both mother and daughter centrioles (PubMed:28625565, PubMed:28428259). Localizes to an axial position on the mother centriole (PubMed:28625565). Localizes to the distal end of the centriole partly on the subdistal appendage region (PubMed:28659385). .
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Tissue Expression:
Ubiquitous. Highly expressed in heart, liver, muscle, kidney, intestine, colon, adrenal gland, prostate, testis, and pancreas.
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Catalog: KA3257C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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