Catalog: KA3225C
Size
Price
Status
Qty.
96well
$330.00
In stock
0
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Collected
Collect
Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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ELISA Kits
Total Claudin-7 Cell-Based Colorimetric ELISA Kit
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Antigen&Target Information
Gene Name:
CLDN7
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Other Name:
Claudin-7 ;
CLDN-7 ;
CLDN-7 ;
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Background:
function:Plays a major role in tight junction-specific obliteration of the intercellular space.,induction:By androgens.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,tissue specificity:Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.,
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Function:
cell adhesion, cell-cell adhesion, calcium-independent cell-cell adhesion, biological adhesion,
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Cellular Localization:
Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane . Cell junction, tight junction . Co-localizes with EPCAM at the basolateral cell membrane and tight junction. .
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Tissue Expression:
Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: KA3225C
Size
Price
Status
Qty.
96well
$330.00
In stock
0
Add to cart
Collected
Collect
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