BAK1

Bcl-2 homologous antagonist/killer ;
Apoptosis regulator BAK ;
Bcl-2-like protein 7 ;
Bcl2-L-7 ;

caution:Could be the product of a pseudogene.,domain:Intact BH3 domain is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. Apoptotic members of the Bcl-2 family.,domain:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.,function:In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the a repressor Bcl-2 or its adenovirus homolog E1B 19k protein.,function:In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the a. repressor BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.,similarity:Belongs to the Bcl-2 family.,subunit:Forms heterodimers with Bcl-2, E1B 19k protein, and Bcl-X(L).,subunit:Interacts with BCL2A1 (By similarity). Homodimer. Formation of the homodimer is zinc-dependent. Forms heterodimers with BCL2, E1B 19k protein, and BCL2L1 isoform Bcl-X(L).,tissue specificity:Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.,

blood vessel development, eye development, cell activation, leukocyte homeostasis, B cell homeostasis, B cell apoptosis, release of cytochrome c from mitochondria, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, vasculature development, blood vessel remodeling, lymphocyte homeostasis, myeloid cell homeostasis, B cell selection, B cell negative selection, immune system development,leukocyte differentiation, reproductive developmental process, mitochondrial transport, cellular ion homeostasis,cellular calcium ion homeostasis, cellular metal ion homeostasis, apoptosis, induction of apoptosis, activation of caspase activity, membrane fusion, mitochondrion organization, mitochondrial membrane organization, sensory organ development, mitochondrial fusion, cell death, cell proliferation, activation of caspase activity by cytochrome c,apoptotic mitochondrial changes, response to radiation, response to fungus, response to abiotic stimulus, response to toxin, post-embryonic development, post-embryonic morphogenesis, response to mycotoxin, response to ionizing radiation, establishment or maintenance of transmembrane electrochemical gradient, response to gamma radiation,regulation of calcium ion transport into cytosol, positive regulation of calcium ion transport into cytosol, negative regulation of phosphorus metabolic process, negative regulation of macromolecule metabolic process, regulation of cell death, positive regulation of cell death, positive regulation of peptidase activity, regulation of metal ion transport,programmed cell death, induction of programmed cell death, membrane organization, death, regulation of phosphate metabolic process, cellular homeostasis, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis, hemopoiesis, lymphocyte differentiation, B cell differentiation, post-embryonic camera-type eye development, regulation of protein modification process, negative regulation of protein modification process,regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, endoplasmic reticulum calcium ion homeostasis, reduction of endoplasmic reticulum calcium ion concentration, regulation of homeostatic process, positive regulation of homeostatic process, cellular component morphogenesis, cell part morphogenesis, regulation of peptidyl-serine phosphorylation, negative regulation of peptidyl-serine phosphorylation,appendage morphogenesis, limb morphogenesis, B cell activation, regulation of phosphorylation, negative regulation of phosphorylation, regulation of membrane potential, homeostatic process, regulation of apoptosis, camera-type eye development, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, positive regulation of catalytic activity, regulation of ion transport, positive regulation of ion transport, positive regulation of caspase activity, regulation of caspase activity, regulation of protein binding,regulation of protein homodimerization activity, regulation of protein heterodimerization activity, positive regulation of molecular function, leukocyte activation, negative regulation of phosphate metabolic process, lymphocyte activation,regulation of mitochondrial membrane permeability, intracellular transport, post-embryonic eye morphogenesis,organelle fusion, blood vessel morphogenesis, hemopoietic or lymphoid organ development, post-embryonic organ morphogenesis, post-embryonic organ development, eye morphogenesis, camera-type eye morphogenesis, post-embryonic camera-type eye morphogenesis, reproductive structure development, appendage development, tissue remodeling, homeostasis of number of cells, chemical homeostasis, ion homeostasis, positive regulation of transport,regulation of binding, regulation of phosphorus metabolic process, negative regulation of protein metabolic process,regulation of hydrolase activity, positive regulation of hydrolase activity, regulation of cell cycle, regulation of mitochondrial membrane potential, regulation of calcium ion transport, positive regulation of calcium ion transport,regulation of peptidase activity, regulation of endopeptidase activity, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis, vagina development,limb development, apoptosis in response to endoplasmic reticulum stress, lymphocyte apoptosis, mitochondrion morphogenesis,

Mitochondrion outer membrane ; Single-pass membrane protein .

Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.