LIMK1/LIMK2

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Haploinsufficiency of LIMK1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. May be involved in brain development.,PTM:Autophosphorylated.,PTM:Phosphorylated on serine and/or threonine residues by ROCK1. May be dephosphorylated and inactivated by SSH1.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 LIM zinc-binding domains.,subunit:Self-associates. The LIM domain interacts with the cytoplasmic domain of NRG1. Binds ROCK1. Interacts with SSH1. Interacts with NISCH.,tissue specificity:Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.,

regulation of cell growth, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cytoskeleton organization, intracellular signaling cascade, small GTPase mediated signal transduction, Ras protein signal transduction, Rho protein signal transduction, regulation of cell size, positive regulation of cell development, regulation of cell morphogenesis involved in differentiation, regulation of neuron projection development, phosphorylation, regulation of cell morphogenesis, actin filament-based process, actin cytoskeleton organization, positive regulation of cell growth, regulation of axon extension, regulation of cell projection organization,positive regulation of cell projection organization, regulation of cellular component size, regulation of growth, positive regulation of cell differentiation, regulation of neuron differentiation, positive regulation of axon extension, positive regulation of cell size, positive regulation of growth, regulation of developmental growth, positive regulation of developmental growth, regulation of neurogenesis, positive regulation of neurogenesis, regulation of axonogenesis,positive regulation of axonogenesis, positive regulation of developmental process, positive regulation of cellular component organization, regulation of nervous system development, regulation of cell development,

Cytoplasm . Nucleus . Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Predominantly found in the cytoplasm. Localizes in the lamellipodium in a CDC42BPA, CDC42BPB and FAM89B/LRAP25-dependent manner. .

Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.