Catalog: KA3140C
Size
Price
Status
Qty.
96well
$330.00
In stock
0
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Collected
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Main Information
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Unmodified
Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
KRT8
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Other Name:
Keratin, type II cytoskeletal 8 ;
Cytokeratin-8 ;
CK-8 ;
Keratin-8 ;
K8 ;
Type-II keratin Kb8 ;
Cytokeratin-8 ;
CK-8 ;
Keratin-8 ;
K8 ;
Type-II keratin Kb8 ;
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Database Link:
Background:
keratin 8(KRT8) Homo sapiens This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012],
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Function:
apoptosis, cytoskeleton organization, cell death, programmed cell death, death, cytokine-mediated signaling pathway,tumor necrosis factor-mediated signaling pathway,
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Cellular Localization:
Cytoplasm . Nucleus, nucleoplasm . Nucleus matrix .
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Tissue Expression:
Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity.
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Reference Citation({{totalcount}})
Catalog: KA3140C
Size
Price
Status
Qty.
96well
$330.00
In stock
0
Add to cart
Collected
Collect
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