GRIA2

Glutamate receptor 2 ;
GluR-2 ;
AMPA-selective glutamate receptor 2 ;
GluR-B ;
GluR-K2 ;
Glutamate receptor ionotropic, AMPA 2 ;
GluA2 ;

function:Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.,miscellaneous:The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.,PTM:Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.,RNA editing:Partially edited. Fully edited in the brain. Heteromerically expressed edited GLUR2 (R) receptor complexes are impermeable to calcium, whereas the unedited (Q) forms are highly permeable to divalent ions.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with PRKCABP, GRIP1 and GRIP2.,

regulation of receptor recycling, ion transport, endocytosis, receptor-mediated endocytosis, cell-cell signaling, synaptic transmission, protein localization, response to inorganic substance, response to metal ion, response to lithium ion,membrane invagination, positive regulation of cell communication, membrane organization, vesicle-mediated transport, transmission of nerve impulse, receptor internalization, regulation of neurological system process, positive regulation of neurological system process, receptor metabolic process, regulation of system process, establishment of protein localization, regulation of synaptic transmission, positive regulation of synaptic transmission, neurological system process, positive regulation of multicellular organismal process, regulation of synaptic transmission, glutamatergic, regulation of transmission of nerve impulse, positive regulation of transmission of nerve impulse,

Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic density membrane ; Multi-pass membrane protein . Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression (By similarity). Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). .