NOS3

Nitric oxide synthase, endothelial ;
Constitutive NOS ;
cNOS ;
EC-NOS ;
Endothelial NOS ;
eNOS ;
NOS type III ;
NOSIII ;

catalytic activity:L-arginine + n NADPH + n H(+) + m O(2) = citrulline + nitric oxide + n NADP(+).,cofactor:Binds 1 FAD.,cofactor:Binds 1 FMN.,cofactor:Heme group.,cofactor:Tetrahydrobiopterin (BH4). May stabilize the dimeric form of the enzyme.,enzyme regulation:Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN.,function:Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.,online information:Nitric oxide synthase entry,polymorphism:Variation in NOS3 seem to be associated with susceptibility to coronary spasm.,similarity:Belongs to the NOS family.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 flavodoxin-like domain.,subcellular location:Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.,subunit:Homodimer. Interacts with NOSIP and NOSTRIN.,tissue specificity:Platelets, placenta, liver and kidney.,

response to acid, angiogenesis, ovulation from ovarian follicle, blood vessel development, response to hypoxia,vasculature development, blood vessel remodeling, regulation of systemic arterial blood pressure by hormone,regulation of sodium ion transport, response to molecule of bacterial origin, reproductive developmental process,muscle system process, circulatory system process, vascular process in circulatory system, regulation of systemic arterial blood pressure mediated by a chemical signal, regulation of systemic arterial blood pressure, regulation of systemic arterial blood pressure by endothelin, regulation of nucleotide metabolic process, arginine metabolic process,arginine catabolic process, nitric oxide biosynthetic process, anti-apoptosis, cell motion, mitochondrion organization,cell surface receptor linked signal transduction, gamete generation, female gamete generation, sex differentiation,aging, blood circulation, regulation of blood pressure, negative regulation of cell proliferation, gonad development,female gonad development, cellular amino acid catabolic process, glutamine family amino acid metabolic process,glutamine family amino acid catabolic process, response to temperature stimulus, amine catabolic process, response to heat, response to bacterium, response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus, response to organic substance, response to inorganic substance, response to metal ion, response to organic nitrogen, response to lead ion, regulation of platelet activation, negative regulation of platelet activation,regulation of cell death, regulation of metal ion transport, response to organic cyclic substance, response to amine stimulus, regulation of muscle hyperplasia, negative regulation of muscle hyperplasia, negative regulation of muscle adaptation, smooth muscle adaptation, smooth muscle hyperplasia, organic acid catabolic process, cell migration,sexual reproduction, ovulation cycle process, regulation of blood coagulation, negative regulation of blood coagulation, respiratory tube development, lung development, ovulation, regulation of cyclic nucleotide metabolic process, regulation of cyclic nucleotide biosynthetic process, regulation of nucleotide biosynthetic process, regulation of cGMP metabolic process, regulation of cGMP biosynthetic process, regulation of cyclase activity, positive regulation of cyclase activity, regulation of guanylate cyclase activity, positive regulation of guanylate cyclase activity,lipopolysaccharide-mediated signaling pathway, regulation of response to external stimulus, response to estradiol stimulus, response to lipopolysaccharide, multicellular organism reproduction, response to cytokine stimulus, response to fluid shear stress, regulation of tube size, tube development, regulation of cell proliferation, regulation of vasodilation, response to drug, ovulation cycle, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, negative regulation of catalytic activity, response to amino acid stimulus, regulation of potassium ion transport, negative regulation of potassium ion transport, regulation of ion transport, negative regulation of ion transport, response to peptide hormone stimulus, muscle adaptation, regulation of muscle adaptation, endothelial cell migration, response to estrogen stimulus, regulation of system process, negative regulation of molecular function, positive regulation of molecular function, nitrogen compound biosynthetic process, development of primary sexual characteristics, response to ethanol, regulation of angiogenesis, positive regulation of angiogenesis, positive regulation of vasodilation, nitric oxide metabolic process, carboxylic acid catabolic process, development of primary female sexual characteristics,female sex differentiation, rhythmic process, blood vessel morphogenesis, response to steroid hormone stimulus,reproductive structure development, reproductive process in a multicellular organism, regulation of smooth muscle cell proliferation, negative regulation of smooth muscle cell proliferation, tissue remodeling, cell motility, regulation of coagulation, negative regulation of coagulation, regulation of cell activation, negative regulation of cell activation,regulation of blood vessel size, endocrine process, negative regulation of transport, positive regulation of developmental process, positive regulation of multicellular organismal process, negative regulation of multicellular organismal process, regulation of hydrolase activity, regulation of lyase activity, negative regulation of hydrolase activity, positive regulation of lyase activity, localization of cell, regulation of calcium ion transport, negative regulation of calcium ion transport, response to hyperoxia, response to lipoprotein stimulus, oxidation reduction, respiratory system development, negative regulation of cell death, response to oxygen levels,

Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.

Platelets, placenta, liver and kidney.