CDK1

Cyclin-dependent kinase 1 ;
CDK1 ;
EC 2.7.11.23 ;
Cell division control protein 2 homolog ;
Cell division protein kinase 1 ;
p34 protein kinase ;

catalytic activity:ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it.,function:Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with DLGAP5. Isoform 2 is unable to complex with cyclin B1 and also fails to bind to the CDK inhibitor p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase.,

cell cycle checkpoint, DNA damage checkpoint, M phase of mitotic cell cycle, mitotic cell cycle, M phase, nuclear division,protein amino acid phosphorylation, proteolysis, ubiquitin-dependent protein catabolic process, phosphorus metabolic process, phosphate metabolic process, anti-apoptosis, response to DNA damage stimulus, cell cycle, mitosis, mitotic cell cycle checkpoint, mitotic cell cycle G2/M transition DNA damage checkpoint, intracellular signaling cascade,regulation of mitotic cell cycle, macromolecule catabolic process, proteasomal protein catabolic process, positive regulation of macromolecule metabolic process, regulation of cell death, phosphorylation, modification-dependent protein catabolic process, cell cycle process, cell cycle phase, protein catabolic process, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, regulation of protein ubiquitination, positive regulation of protein ubiquitination, regulation of protein modification process, positive regulation of protein modification process, DNA integrity checkpoint, G2/M transition DNA damage checkpoint, G2/M transition checkpoint,regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, cellular response to stress, DNA damage response, signal transduction, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, proteasomal ubiquitin-dependent protein catabolic process, modification-dependent macromolecule catabolic process, positive regulation of molecular function, cellular protein catabolic process, cellular macromolecule catabolic process, organelle fission, positive regulation of protein metabolic process, cell division, regulation of ligase activity, positive regulation of ligase activity, positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle, regulation of ubiquitin-protein ligase activity, regulation of ubiquitin-protein ligase activity during mitotic cell cycle, positive regulation of ubiquitin-protein ligase activity, proteolysis involved in cellular protein catabolic process,regulation of cell cycle, negative regulation of cell death,

Nucleus. Cytoplasm. Mitochondrion . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle. Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.

Isoform 2 is found in breast cancer tissues.