CAV1

Caveolin-1

disease:Defects in CAV1 are the cause of congenital generalized lipodystrophy type 3 (CGL3) [MIM:612526]; also called Berardinelli-Seip congenital lipodystrophy type 3 (BSCL3). Congenital generalized lipodystrophies are autosomal recessive disorders characterized by a near absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes.,function:May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.,online information:Caveolin entry,PTM:The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.,similarity:Belongs to the caveolin family.,subcellular location:Potential hairpin-like structure in the membrane. Membrane protein of caveolae.,subunit:Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4.,tissue specificity:In muscle and lung, less so in liver, brain and kidney.,

MAPKKK cascade, inactivation of MAPK activity, microtubule cytoskeleton organization, blood vessel development,vasculogenesis, response to hypoxia, membrane raft formation, regulation of protein amino acid phosphorylation,negative regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation,regulation of endothelial cell proliferation, negative regulation of endothelial cell proliferation, vasculature development, regulation of cytokine-mediated signaling pathway, negative regulation of cytokine-mediated signaling pathway, circulatory system process, vascular process in circulatory system, protein complex assembly, negative regulation of protein kinase activity, neutral lipid metabolic process, acylglycerol metabolic process, triglyceride metabolic process, glycerol ether metabolic process, ion transport, cation transport, calcium ion transport, lipid transport, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, endocytosis,regulation of muscle contraction, regulation of smooth muscle contraction, cytoskeleton organization, microtubule-based process, intracellular signaling cascade, protein kinase cascade, muscle organ development, skeletal muscle tissue development, response to nutrient, lactation, blood circulation, protein localization, negative regulation of cell proliferation, cellular response to starvation, response to radiation, response to mechanical stimulus, response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus, negative regulation of biosynthetic process, positive regulation of signal transduction, negative regulation of signal transduction, response to extracellular stimulus, response to organic substance, response to inorganic substance, response to metal ion,response to ionizing radiation, membrane invagination, response to gamma radiation, regulation of calcium ion transport into cytosol, positive regulation of calcium ion transport into cytosol, positive regulation of phosphorus metabolic process, negative regulation of phosphorus metabolic process, regulation of cellular ketone metabolic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, regulation of protein kinase cascade, positive regulation of organelle organization, positive regulation of cell communication, negative regulation of cell communication, negative regulation of protein kinase cascade, lipid localization, regulation of metal ion transport, striated muscle tissue development, di-, tri-valent inorganic cation transport, sterol transport, membrane organization, vesicle organization, vesicle-mediated transport, organic ether metabolic process, regulation of lipid metabolic process, regulation of fatty acid metabolic process, regulation of phosphate metabolic process, regulation of vasoconstriction, cellular homeostasis, lipid storage, gland morphogenesis, metal ion transport, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis,regulation of endocytosis, regulation of blood coagulation, cholesterol transport, regulation of BMP signaling pathway,negative regulation of BMP signaling pathway, regulation of epithelial cell differentiation, negative regulation of epithelial cell differentiation, mammary gland development, microtubule polymerization or depolymerization, regulation of microtubule polymerization or depolymerization, positive regulation of microtubule polymerization or depolymerization, regulation of microtubule polymerization, positive regulation of microtubule polymerization, negative regulation of cellular biosynthetic process, positive regulation of protein complex assembly, regulation of protein modification process, negative regulation of protein modification process, positive regulation of protein modification process, membrane raft organization, response to nutrient levels, cellular response to extracellular stimulus, cellular response to nutrient levels, response to corticosteroid stimulus, regulation of response to external stimulus,regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of protein polymerization, positive regulation of protein polymerization, multicellular organism reproduction, maintenance of protein location in cell, response to progesterone stimulus, regulation of homeostatic process, positive regulation of homeostatic process, regulation of microtubule-based process, regulation of organelle organization, regulation of peptidyl-serine phosphorylation, negative regulation of peptidyl-serine phosphorylation, positive regulation of peptidyl-serine phosphorylation, cholesterol efflux,gas homeostasis, nitric oxide homeostasis, cellular response to stress, negative regulation of kinase activity, cellular macromolecular complex subunit organization, cellular macromolecular complex assembly, regulation of tube size,regulation of cell proliferation, vasoconstriction, regulation of vasodilation, regulation of phosphorylation, negative regulation of phosphorylation, positive regulation of phosphorylation, regulation of membrane potential, response to drug, regulation of tyrosine phosphorylation of STAT protein, regulation of tyrosine phosphorylation of Stat5 protein,negative regulation of tyrosine phosphorylation of Stat5 protein, negative regulation of tyrosine phosphorylation of STAT protein, homeostatic process, response to starvation, cholesterol homeostasis, positive regulation of catalytic activity, negative regulation of catalytic activity, regulation of protein complex assembly, regulation of ion transport,positive regulation of ion transport, regulation of MAP kinase activity, negative regulation of MAP kinase activity,regulation of MAPKKK cascade, negative regulation of MAPKKK cascade, regulation of kinase activity, cellular protein complex assembly, response to estrogen stimulus, macromolecular complex subunit organization, regulation of system process, regulation of cellular component biogenesis, negative regulation of molecular function, positive regulation of molecular function, negative regulation of nitric oxide biosynthetic process, maintenance of protein location, regulation of nitric oxide biosynthetic process, negative regulation of cell differentiation, regulation of anti-apoptosis, positive regulation of anti-apoptosis, positive regulation of endocytosis, regulation of protein kinase activity, positive regulation of vasoconstriction, negative regulation of vasodilation, negative regulation of phosphate metabolic process, positive regulation of phosphate metabolic process, regulation of JAK-STAT cascade, negative regulation of JAK-STAT cascade, glycerolipid metabolic process, microtubule polymerization, blood vessel morphogenesis, response to steroid hormone stimulus, regulation of metalloenzyme activity, positive regulation of metalloenzyme activity,reproductive process in a multicellular organism, gland development, tissue remodeling, chemical homeostasis,regulation of peptidyl-tyrosine phosphorylation, negative regulation of peptidyl-tyrosine phosphorylation, ion homeostasis, regulation of coagulation, regulation of blood vessel size, positive regulation of transport, positive regulation of cellular component organization, negative regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, maintenance of location, positive regulation of multicellular organismal process,negative regulation of multicellular organismal process, positive regulation of protein metabolic process, negative regulation of protein metabolic process, protein polymerization, protein oligomerization, protein homooligomerization,regulation of hydrolase activity, regulation of transferase activity, negative regulation of transferase activity, response to glucocorticoid stimulus, cytosolic calcium ion homeostasis, regulation of cytoskeleton organization, positive regulation of cytoskeleton organization, response to calcium ion, maintenance of location in cell, membrane depolarization, regulation of calcium ion transport, positive regulation of calcium ion transport, regulation of peptidase activity, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis, lipid homeostasis, sterol homeostasis, mammary gland involution,mammary gland morphogenesis, muscle tissue development, skeletal muscle organ development, regulation of vesicle-mediated transport, macromolecular complex assembly, protein complex biogenesis, response to oxygen levels, regulation of microtubule cytoskeleton organization,

Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola ; Peripheral membrane protein. Membrane raft . Golgi apparatus, trans-Golgi network . Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.

Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.