Contact Us

408-747-0189
1-877-594-3616

Quick order

Total Bad Cell-Based Colorimetric ELISA Kit

-KA3039C

Catalog: KA3039C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service
Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
Related Products
Primary Antibodies
Bad Rabbit pAb
YT0436

More→

Primary Antibodies
Bad Rabbit pAb
YT0435

More→

Primary Antibodies
Bad Rabbit pAb
YT0434

More→

Primary Antibodies
Bad Rabbit pAb
YT0433

More→

Primary Antibodies
Bad Rabbit pAb
YT0432

More→

Primary Antibodies
Bad (Phospho Ser134) Rabbit pAb
YP0910

More→

Primary Antibodies
Bad (Phospho Ser91) Rabbit pAb
YP0725

More→

Primary Antibodies
Bad (Phospho Ser155) Rabbit pAb
YP0030

More→

Primary Antibodies
Bad (Phospho Ser136) Rabbit pAb
YP0029

More→

Primary Antibodies
Bad (Phospho Ser112) Rabbit pAb
YP0028

More→

ELISA Kits
Total Bad Cell-Based Colorimetric ELISA Kit
KA3040C

More→

ELISA Kits
Total Bad Cell-Based Colorimetric ELISA Kit
KA3039C

More→

ELISA Kits
Total Bad Cell-Based Colorimetric ELISA Kit
KA3038C

More→

ELISA Kits
Total Bad Cell-Based Colorimetric ELISA Kit
KA3037C

More→

ELISA Kits
BAD (Phospho Ser112) Cell-Based Colorimetric ELISA Kit
KA1547C

More→

ELISA Kits
BAD (Phospho Ser134) Cell-Based Colorimetric ELISA Kit
KA1424C

More→

ELISA Kits
BAD (Phospho Ser91/128) Cell-Based Colorimetric ELISA Kit
KA1423C

More→

ELISA Kits
Bad (Phospho Ser155) Cell-Based Colorimetric ELISA Kit
KA1029C

More→

ELISA Kits
Bad (Phospho Ser136) Cell-Based Colorimetric ELISA Kit
KA1028C

More→

Antigen&Target Information
Gene Name:
BAD
show all
Other Name:
Bcl2 antagonist of cell death ;
BAD ;
Bcl-2-binding component 6 ;
Bcl-2-like protein 8 ;
Bcl2-L-8 ;
Bcl-XL/Bcl-2-associated death promoter ;
show all
Database Link:
Organism Gene ID SwissProt
Human 572; Q92934;
Mouse Q61337;
Rat O35147;
Background:
domain:Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.,function:Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.,online information:Bcl 2-associated death promoter entry,PTM:Phosphorylated on one or more of Ser-75, Ser-99, Ser-118 and Ser-134 in response to survival stimuli, which blocks its pro-apoptotic activity. Phosphorylation on Ser-99 or Ser-75 promotes heterodimerization with 14-3-3 proteins. This interaction then facilitates the phosphorylation at Ser-118, a site within the BH3 motif, leading to the release of Bcl-X(L) and the promotion of cell survival. Ser-99 is the major site of AKT/PKB phosphorylation, Ser-118 the major site of protein kinase A (CAPK) phosphorylation.,similarity:Belongs to the Bcl-2 family.,subcellular location:Upon phosphorylation, locates to the cytoplasm.,subunit:Forms heterodimers with the anti-apoptotic proteins, Bcl-X(L), Bcl-2 and Bcl-W. Also binds protein S100A10 (By similarity). The Ser-75/Ser-99 phosphorylated form binds 14-3-3 proteins.,tissue specificity:Expressed in a wide variety of tissues.,
show all
Function:
positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, monosaccharide metabolic process, glucose metabolic process, glucose catabolic process, apoptosis,induction of apoptosis, cell death, cell proliferation, induction of apoptosis by extracellular signals, activation of pro-apoptotic gene products, regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death, carbohydrate catabolic process, death, cytokine-mediated signaling pathway, hexose metabolic process, hexose catabolic process, carbohydrate homeostasis, homeostatic process, glucose homeostasis,regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of caspase activity, cellular carbohydrate catabolic process, regulation of B cell differentiation, positive regulation of B cell differentiation, regulation of T cell differentiation, positive regulation of T cell differentiation, positive regulation of cell differentiation, regulation of lymphocyte differentiation, positive regulation of lymphocyte differentiation, alcohol catabolic process, monosaccharide catabolic process, chemical homeostasis,regulation of T cell activation, regulation of B cell activation, regulation of cell activation, positive regulation of cell activation, positive regulation of T cell activation, positive regulation of B cell activation, positive regulation of developmental process, regulation of lymphocyte activation, positive regulation of lymphocyte activation, regulation of hydrolase activity, regulation of peptidase activity, regulation of endopeptidase activity,
show all
Cellular Localization:
Mitochondrion outer membrane. Cytoplasm . Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm. .
show all
Tissue Expression:
Expressed in a wide variety of tissues.
show all
Signaling Pathway
Cellular Processes >> Transport and catabolism >> Autophagy - animal Cellular Processes >> Cell growth and death >> Apoptosis Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion Organismal Systems >> Immune system >> Chemokine signaling pathway Organismal Systems >> Endocrine system >> Insulin signaling pathway Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway Organismal Systems >> Nervous system >> Neurotrophin signaling pathway Human Diseases >> Cancer: overview >> Pathways in cancer Human Diseases >> Cancer: specific types >> Colorectal cancer Human Diseases >> Cancer: specific types >> Pancreatic cancer Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma Human Diseases >> Cancer: specific types >> Acute myeloid leukemia Human Diseases >> Cancer: specific types >> Chronic myeloid leukemia Human Diseases >> Cancer: specific types >> Melanoma Human Diseases >> Cancer: specific types >> Renal cell carcinoma Human Diseases >> Cancer: specific types >> Prostate cancer Human Diseases >> Cancer: specific types >> Endometrial cancer Human Diseases >> Cancer: specific types >> Non-small cell lung cancer Human Diseases >> Neurodegenerative disease >> Alzheimer disease Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis Human Diseases >> Neurodegenerative disease >> Prion disease Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases Environmental Information Processing >> Signal transduction >> ErbB signaling pathway Environmental Information Processing >> Signal transduction >> Ras signaling pathway Environmental Information Processing >> Signal transduction >> VEGF signaling pathway Environmental Information Processing >> Signal transduction >> cAMP signaling pathway Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Catalog: KA3039C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

Toggle night Mode

{{pinfoXq.title || ''}}

Catalog: {{pinfoXq.catalog || ''}}
Filter:

All

{{item.name}}

{{pinfo.title}}
-{{pinfo.catalog}}

Filter:

{{item.descr}}

Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Learn more
Product {{index}}/{{pcount}}
Prev
Next

{{pvTitle}}

Scroll wheel zooms the picture
{{pvDescr}}