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Total CREB-2 Cell-Based Colorimetric ELISA Kit

-KA3034C

Catalog: KA3034C
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96well
$330.00
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Main Information
Reactivity

Human

Applications

ELISA

Conjugate/Modification


Unmodified

Detailed Information
Storage
2-8°C/6 months
Modification
Unmodified
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
ATF4
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Other Name:
Cyclic AMP-dependent transcription factor ATF-4 ;
cAMP-dependent transcription factor ATF-4 ;
Activating transcription factor 4 ;
Cyclic AMP-responsive element-binding protein 2 ;
CREB-2 ;
cAMP-responsive element-binding protein 2 ;
DNA-binding protein TAXREB67 ;
Tax-responsive enhancer element-binding protein 67 ;
TaxREB67 ;
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Database Link:
Organism Gene ID SwissProt
Human 468; P18848;
Mouse Q06507;
Background:
function:Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I.,similarity:Belongs to the bZIP family.,similarity:Contains 1 bZIP domain.,subcellular location:Colocalizes with GABBR1 in hippocampal neuron dendritic membranes.,subunit:Interacts with the C-terminal region of GABBR1 via the leucine zipper of its C-terminal bZIP domain. Interacts with the C-terminal region of GABBR2 (By similarity). Binds DNA as a homo-or heterodimer. Interacts with the N-terminal region of CEP290.,
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Function:
monosaccharide metabolic process, glucose metabolic process, pyruvate metabolic process, gluconeogenesis,transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter,positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, carbohydrate biosynthetic process, hexose metabolic process, hexose biosynthetic process, positive regulation of cellular biosynthetic process,cellular response to stress, cellular carbohydrate biosynthetic process, response to endoplasmic reticulum stress,regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, alcohol biosynthetic process, monosaccharide biosynthetic process,positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process,
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Cellular Localization:
Nucleus . Nucleus speckle . Cytoplasm . Cell membrane . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity). Colocalizes with NEK6 at the centrosome (PubMed:20873783). Recruited to nuclear speckles following interaction with EP300/p300 (PubMed:16219772). .
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Mitophagy - animal Cellular Processes >> Cell growth and death >> Apoptosis Organismal Systems >> Endocrine system >> Insulin secretion Organismal Systems >> Endocrine system >> Glucagon signaling pathway Organismal Systems >> Endocrine system >> GnRH signaling pathway Organismal Systems >> Endocrine system >> Estrogen signaling pathway Organismal Systems >> Endocrine system >> Relaxin signaling pathway Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes Organismal Systems >> Nervous system >> Cholinergic synapse Organismal Systems >> Nervous system >> Dopaminergic synapse Organismal Systems >> Nervous system >> Neurotrophin signaling pathway Organismal Systems >> Aging >> Longevity regulating pathway Human Diseases >> Cancer: specific types >> Prostate cancer Human Diseases >> Neurodegenerative disease >> Alzheimer disease Human Diseases >> Neurodegenerative disease >> Parkinson disease Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis Human Diseases >> Neurodegenerative disease >> Prion disease Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases Environmental Information Processing >> Signal transduction >> MAPK signaling pathway Environmental Information Processing >> Signal transduction >> TNF signaling pathway Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Catalog: KA3034C
Size
Price
Status
Qty.
96well
$330.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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