Detects endogenous levels of MKP-1/2 only when phosphorylated at Human:S296/318, Mouse:S296/322, Rat:S296/319.

DUSP1/4

catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Dual specificity phosphatase that dephosphorylates MAP kinase ERK2 on both 'Thr-183' and 'Tyr-185'.,induction:By oxidative stress and heat shock.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 rhodanese domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.,

response to reactive oxygen species, protein amino acid dephosphorylation, phosphorus metabolic process,phosphate metabolic process, response to oxidative stress, cell cycle, intracellular signaling cascade, response to nutrient, response to radiation, response to light stimulus, response to abiotic stimulus, response to endogenous stimulus, response to hormone stimulus, response to extracellular stimulus, response to organic substance, response to inorganic substance, response to metal ion, regulation of cell death, positive regulation of cell death,dephosphorylation, response to nutrient levels, response to corticosteroid stimulus, response to estradiol stimulus,response to retinoic acid, cellular response to hormone stimulus, response to vitamin A, response to vitamin, response to testosterone stimulus, response to hydrogen peroxide, regulation of apoptosis, positive regulation of apoptosis,regulation of programmed cell death, positive regulation of programmed cell death, response to estrogen stimulus,regulation of anti-apoptosis, positive regulation of anti-apoptosis, response to steroid hormone stimulus, response to glucocorticoid stimulus, response to cAMP, response to calcium ion,

Nucleus .

Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.