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MAPKAPK5 (Phospho Thr182) Cell-Based Colorimetric ELISA Kit

-KA1752C

Catalog: KA1752C
Size
Price
Status
Qty.
96well
$470.00
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Main Information
Reactivity

Human, Mouse

Applications

ELISA

Conjugate/Modification


Phospho

Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
MAPKAPK5
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Other Name:
MAP kinase-activated protein kinase 5 ;
MAPK-activated protein kinase 5 ;
MAPKAP kinase 5 ;
MAPKAP-K5 ;
MAPKAPK-5 ;
MK-5 ;
MK5 ;
p38-regulated/activated protein kinase ;
PRAK ;
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Database Link:
Organism Gene ID SwissProt
Human 8550; Q8IW41;
Mouse O54992;
Background:
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:p38 alpha and beta-dependent phosphorylation increases its activity. Activated by stress-related extracellular stimuli; such as H(2)O(2), arsenite, anisomycin TNF alpha and also PMA and the calcium ionophore A23187; but to a lesser extent. In vitro, activated by SQSTM1.,function:Mediates stress-induced small heat shock protein 27 phosphorylation.,PTM:Phosphorylated on Thr-182; which is the regulatory phosphorylation site and is located on the T-loop/loop 12.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subcellular location:Also observed in the nucleus.,subunit:Interacts with SQSTM1.,tissue specificity:Expressed ubiquitously.,
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Function:
protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, phosphorylation,
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Cellular Localization:
Cytoplasm. Nucleus. Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.
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Tissue Expression:
Expressed ubiquitously.
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Catalog: KA1752C
Size
Price
Status
Qty.
96well
$470.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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