ATRIP

ATR-interacting protein ;
ATM and Rad3-related-interacting protein ;

caution:The gene for this protein is either identical to or adjacent to that of TREX1. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame.,domain:The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.,function:Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.,PTM:Phosphorylated by ATR.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the ATRIP family.,subcellular location:Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA. Interacts with CEP164 (via N-terminus).,tissue specificity:Ubiquitous.,

cell cycle checkpoint, DNA damage checkpoint, DNA metabolic process, DNA replication, DNA repair, response to DNA damage stimulus, intracellular signaling cascade, DNA integrity checkpoint, cellular response to stress, DNA damage response, signal transduction, regulation of cell cycle,

Nucleus . Redistributes to discrete nuclear foci upon DNA damage.

Ubiquitous.