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PAK3 (Phospho Ser154) Cell-Based Colorimetric ELISA Kit

-KA1716C

Catalog: KA1716C
Size
Price
Status
Qty.
96well
$470.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Phospho

Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
PAK3
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Other Name:
Serine/threonine-protein kinase PAK 3 ;
Beta-PAK ;
Oligophrenin-3 ;
p21-activated kinase 3 ;
PAK-3 ;
show all
Database Link:
Organism Gene ID SwissProt
Human 5063; O75914;
Mouse Q61036;
Rat Q62829;
Background:
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,disease:Defects in PAK3 are the cause of mental retardation X-linked type 30 (MRX30) [MIM:300558]; also called X-linked mental retardation type 47 (MRX47). Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.,enzyme regulation:Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-436 and allows the kinase domain to adopt an active structure.,function:Key regulator of synapse formation and plasticity in the hippocampus.,PTM:Autophosphorylated when activated by CDC42/p21.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts tightly with GTP-bound but not GDP-bound CDC42/p21 and RAC1. Shows highly specific binding to the SH3 domains of phospholipase C-gamma and of adapter protein NCK.,tissue specificity:Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.,
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Function:
protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, phosphorylation,
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Cellular Localization:
Cytoplasm .
show all
Tissue Expression:
Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus.
show all
Catalog: KA1716C
Size
Price
Status
Qty.
96well
$470.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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