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MNK1 (Phospho Thr255) Cell-Based Colorimetric ELISA Kit

-KA1710C

Catalog: KA1710C
Size
Price
Status
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96well
$470.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Phospho

Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
MKNK1
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Other Name:
MAP kinase-interacting serine/threonine-protein kinase 1 ;
MAP kinase signal-integrating kinase 1 ;
MAPK signal-integrating kinase 1 ;
Mnk1 ;
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Database Link:
Organism Gene ID SwissProt
Human 8569; Q9BUB5;
Mouse 17346; O08605;
Rat 500526; Q4G050;
Background:
MAP kinase interacting serine/threonine kinase 1(MKNK1) Homo sapiens This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012],
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Phosphorylated and activated by the p38 kinases and kinases in the Erk pathway.,Function:May play a role in the response to environmental stress and cytokines. Appears to regulate transcription by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap.,PTM:Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with the C-terminal regions of EIF4G1 and EIF4G2. Also binds to dephosphorylated ERK1 and ERK2, and to the p38 kinases.,tissue specificity:Ubiquitous.,
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Cellular Localization:
[Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm. Nucleus.
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Tissue Expression:
Ubiquitous.
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Catalog: KA1710C
Size
Price
Status
Qty.
96well
$470.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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