HNF4A

Hepatocyte nuclear factor 4-alpha ;
HNF-4-alpha ;
Nuclear receptor subfamily 2 group A member 1 ;
Transcription factor 14 ;
TCF-14 ;
Transcription factor HNF-4 ;

alternative products:Additional isoforms seem to exist,disease:Defects in HNF4A are the cause of maturity onset diabetes of the young type 1 (MODY1) [MIM:125850]; also shortened MODY-1. MODY [MIM:606391] is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age) and a primary defect in insulin secretion. The clinical phenotype of MODY1 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications.,function:Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.,miscellaneous:Binds fatty acids.,online information:Hepatocyte nuclear factors entry,PTM:Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution.,similarity:Belongs to the nuclear hormone receptor family.,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Homodimerization is required for HNF4-alpha to bind to its recognition site.,

regulation of cell growth, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, regulation of carbohydrate metabolic process, regulation of gluconeogenesis, transcription,regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, ornithine metabolic process, acyl-CoA metabolic process, coenzyme metabolic process, xenobiotic metabolic process,establishment of tissue polarity, regulation of mitotic cell cycle, blood coagulation, hemostasis, negative regulation of cell proliferation, regulation of cell size, response to xenobiotic stimulus, response to wounding, response to carbohydrate stimulus, response to hexose stimulus, response to glucose stimulus, positive regulation of biosynthetic process, negative regulation of signal transduction, response to organic substance, regulation of specific transcription from RNA polymerase II promoter, positive regulation of specific transcription from RNA polymerase II promoter,positive regulation of macromolecule biosynthetic process, negative regulation of phosphorus metabolic process,regulation of cellular ketone metabolic process, positive regulation of macromolecule metabolic process, negative regulation of macromolecule metabolic process, regulation of protein kinase cascade, positive regulation of gene expression, negative regulation of cell communication, regulation of cellular carbohydrate metabolic process, positive regulation of cellular carbohydrate metabolic process, negative regulation of protein kinase cascade, regulation of glucose metabolic process, positive regulation of glucose metabolic process, regulation of lipid metabolic process,regulation of fatty acid metabolic process, regulation of phosphate metabolic process, negative regulation of cell growth, positive regulation of cellular biosynthetic process, regulation of protein modification process, negative regulation of protein modification process, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, regulation of intracellular transport, negative regulation of intracellular transport,regulation of cellular component size, regulation of gene-specific transcription, regulation of protein localization,regulation of intracellular protein transport, regulation of protein import into nucleus, translocation, negative regulation of protein import into nucleus, translocation, response to monosaccharide stimulus, cell junction organization, regulation of growth, wound healing, regulation of cell proliferation, regulation of fatty acid biosynthetic process, regulation of protein import into nucleus, regulation of phosphorylation, negative regulation of phosphorylation, regulation of tyrosine phosphorylation of STAT protein, regulation of tyrosine phosphorylation of Stat5 protein, negative regulation of tyrosine phosphorylation of Stat5 protein, negative regulation of tyrosine phosphorylation of STAT protein, homeostatic process, positive regulation of gene-specific transcription, regulation of carbohydrate biosynthetic process, negative regulation of DNA binding, negative regulation of transcription factor activity, negative regulation of molecular function, cell-cell junction organization, regulation of transcription, positive regulation of gluconeogenesis, positive regulation of fatty acid biosynthetic process, negative regulation of cell cycle,negative regulation of cell size, positive regulation of lipid metabolic process, positive regulation of transcription, DNA-dependent, positive regulation of carbohydrate metabolic process, positive regulation of fatty acid metabolic process,negative regulation of growth, negative regulation of mitotic cell cycle, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, negative regulation of phosphate metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, regulation of JAK-STAT cascade,negative regulation of JAK-STAT cascade, regulation of nucleocytoplasmic transport, positive regulation of lipid biosynthetic process, regulation of lipid biosynthetic process, chemical homeostasis, regulation of peptidyl-tyrosine phosphorylation, negative regulation of peptidyl-tyrosine phosphorylation, coagulation, regulation of body fluid levels,negative regulation of transport, regulation of transcription factor activity, regulation of binding, negative regulation of binding, regulation of DNA binding, positive regulation of nitrogen compound metabolic process, regulation of phosphorus metabolic process, cofactor metabolic process, regulation of protein transport, negative regulation of protein transport, negative regulation of protein metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, regulation of cell cycle, lipid homeostasis, regulation of cellular localization,regulation of growth hormone receptor signaling pathway, regulation of establishment of protein localization,

Nucleus.