Catalog: KA1576C
Size
Price
Status
Qty.
96well
$470.00
In stock
0
Add to cart
Collected
Collect
Main Information
Reactivity
Human, Mouse
Applications
ELISA
Conjugate/Modification
Phospho
Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
GAB1
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Other Name:
GRB2-associated-binding protein 1 ;
GRB2-associated binder 1 ;
Growth factor receptor bound protein 2-associated protein 1 ;
GRB2-associated binder 1 ;
Growth factor receptor bound protein 2-associated protein 1 ;
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Background:
GRB2 associated binding protein 1(GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
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Function:
Function:Probably involved in EGF and insulin receptor signaling.,PTM:Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2.,
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Signaling Pathway
Organismal Systems >> Nervous system >> Neurotrophin signaling pathway
Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma
Human Diseases >> Cancer: specific types >> Gastric cancer
Human Diseases >> Cancer: specific types >> Renal cell carcinoma
Environmental Information Processing >> Signal transduction >> ErbB signaling pathway
Environmental Information Processing >> Signal transduction >> Ras signaling pathway
Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway
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Catalog: KA1576C
Size
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Status
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96well
$470.00
In stock
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Add to cart
Collected
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