VDR

Vitamin D3 receptor ;
VDR ;
1,25-dihydroxyvitamin D3 receptor ;
Nuclear receptor subfamily 1 group I member 1 ;

caution:It is uncertain whether Met-1 or Met-4 is the initiator.,disease:Defects in VDR are the cause of type IIA rickets [MIM:277440]; also known as hypocalcemic vitamin D-resistant rickets (HVDRR). HVDRR is most frequently an autosomal recessive disorder characterized by severe rickets, hypocalcemia and secondary hyperparathyroidism.,domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,function:Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.,online information:The Singapore human mutation and polymorphism database,polymorphism:Genetic variations in VDR may determine Mycobacterium tuberculosis susceptibility [MIM:607948].,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF.,

negative regulation of transcription from RNA polymerase II promoter, skeletal system development, placenta development, maternal placenta development, reproductive developmental process, transcription, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, ion transport, cation transport, calcium ion transport, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, induction of apoptosis, intracellular signaling cascade, female pregnancy, response to nutrient,digestion, negative regulation of cell proliferation, induction of apoptosis by extracellular signals, induction of apoptosis by hormones, negative regulation of biosynthetic process, response to extracellular stimulus, regulation of specific transcription from RNA polymerase II promoter, negative regulation of specific transcription from RNA polymerase II promoter, negative regulation of macromolecule biosynthetic process, negative regulation of macromolecule metabolic process, negative regulation of gene expression, regulation of cell death, positive regulation of cell death, regulation of vitamin D 24-hydroxylase activity, positive regulation of vitamin D 24-hydroxylase activity,induction of programmed cell death, di-, tri-valent inorganic cation transport, negative regulation of transcription,cellular homeostasis, digestive system process, metal ion transport, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis, intracellular receptor-mediated signaling pathway, negative regulation of cellular biosynthetic process, response to nutrient levels, cellular response to extracellular stimulus, cellular response to nutrient levels, cellular response to nutrient, negative regulation of gene-specific transcription, regulation of gene-specific transcription, regulation of monooxygenase activity, response to vitamin, response to vitamin D, induction of programmed cell death by hormones, regulation of cell proliferation, homeostatic process, regulation of apoptosis,positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death,positive regulation of catalytic activity, positive regulation of molecular function, regulation of transcription, negative regulation of transcription, DNA-dependent, negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, decidualization, chemical homeostasis, ion homeostasis, intestinal absorption, negative regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, negative regulation of RNA metabolic process, regulation of oxidoreductase activity, positive regulation of oxidoreductase activity, metal ion homeostasis,di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis, regulation of calcidiol 1-monooxygenase activity, vitamin D receptor signaling pathway,

Nucleus . Cytoplasm . Localizes mainly to the nucleus (PubMed:28698609, PubMed:12145331). Localization to the nucleus is enhanced by vitamin D3. .