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TOP2A (Phospho Ser1106) Cell-Based Colorimetric ELISA Kit

-KA1510C

Catalog: KA1510C
Size
Price
Status
Qty.
96well
$470.00
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Main Information
Reactivity

Human

Applications

ELISA

Conjugate/Modification


Phospho

Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
TOP2A
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Other Name:
DNA topoisomerase 2-alpha ;
DNA topoisomerase II, alpha isozyme ;
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Database Link:
Organism Gene ID SwissProt
Human 7153; P11388;
Mouse Q01320;
Background:
catalytic activity:ATP-dependent breakage, passage and rejoining of double-stranded DNA.,enzyme regulation:Specifically inhibited by the intercalating agent amsacrine.,function:Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.,miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.,PTM:Phosphorylation has no effect on catalytic activity.,similarity:Belongs to the type II topoisomerase family.,subcellular location:Generally located in the nucleoplasm.,subunit:Homodimer. Interacts with COPS5.,
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Function:
DNA metabolic process, DNA replication, DNA topological change, DNA ligation, DNA repair, DNA packaging, apoptosis,response to DNA damage stimulus, nucleus organization, chromosome segregation, intracellular signaling cascade, cell death, regulation of cell death, positive regulation of cell death, programmed cell death, death, second-messenger-mediated signaling, chromosome condensation, apoptotic nuclear changes, apoptotic chromosome condensation,cellular response to stress, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of viral genome replication, positive regulation of viral genome replication, regulation of retroviral genome replication, positive regulation of retroviral genome replication,phosphoinositide-mediated signaling, positive regulation of viral reproduction, regulation of viral reproduction,chromosome organization,
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Cellular Localization:
Cytoplasm . Nucleus, nucleoplasm . Nucleus . Nucleus, nucleolus .
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Tissue Expression:
Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in high-grade lymphomas, squamous cell lung tumors and seminomas (PubMed:9155056).
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Catalog: KA1510C
Size
Price
Status
Qty.
96well
$470.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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