CD40

Tumor necrosis factor receptor superfamily member 5 ;
B-cell surface antigen CD40 ;
Bp50 ;
CD40L receptor ;
CDw40 ;
CD antigen CD40 ;

alternative products:Additional isoforms seem to exist,disease:Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3) [MIM:606843]. HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.,function:Receptor for TNFSF5/CD40LG.,online information:CD40 entry,online information:CD40 mutation db,similarity:Contains 4 TNFR-Cys repeats.,subunit:Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6.,tissue specificity:B-cells and in primary carcinomas.,

regulation of DNA recombination, cell activation, regulation of cytokine production, positive regulation of cytokine production, regulation of immunoglobulin production, positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, regulation of immune effector process, regulation of production of molecular mediator of immune response, regulation of leukocyte mediated immunity, regulation of lymphocyte mediated immunity, regulation of B cell mediated immunity, immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway, regulation of adaptive immune response, regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains, regulation of immunoglobulin mediated immune response, protein complex assembly, defense response, inflammatory response, cell surface receptor linked signal transduction, blood coagulation, hemostasis, cell proliferation, positive regulation of cell proliferation, response to wounding, positive regulation of signal transduction, positive regulation of macromolecule metabolic process, regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade, platelet activation,regulation of B cell proliferation, positive regulation of B cell proliferation, regulation of interleukin-12 production,positive regulation of interleukin-12 production, regulation of protein localization, mononuclear cell proliferation,regulation of mononuclear cell proliferation, positive regulation of mononuclear cell proliferation, wound healing, B cell proliferation, B cell activation, regulation of cell proliferation, regulation of I-kappaB kinase/NF-kappaB cascade,positive regulation of I-kappaB kinase/NF-kappaB cascade, macromolecular complex subunit organization, regulation of isotype switching, leukocyte activation, positive regulation of isotype switching, positive regulation of DNA recombination, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process,lymphocyte activation, lymphocyte proliferation, regulation of isotype switching to IgG isotypes, positive regulation of isotype switching to IgG isotypes, regulation of lymphocyte proliferation, positive regulation of lymphocyte proliferation, regulation of protein secretion, coagulation, regulation of B cell activation, regulation of cell activation,positive regulation of cell activation, positive regulation of B cell activation, regulation of body fluid levels, regulation of immunoglobulin secretion, regulation of secretion, regulation of DNA metabolic process, positive regulation of DNA metabolic process, positive regulation of nitrogen compound metabolic process, regulation of protein transport,positive regulation of multicellular organismal process, regulation of lymphocyte activation, positive regulation of lymphocyte activation, regulation of cellular localization, macromolecular complex assembly, regulation of establishment of protein localization, protein complex biogenesis, leukocyte proliferation, regulation of leukocyte proliferation, positive regulation of leukocyte proliferation,

[Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.

B-cells and in primary carcinomas.