function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.,PTM:Constitutively sumoylated by UBE2I.,similarity:Belongs to the CDC37 family.,subunit:Forms a complex with Hsp90. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1.,
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Function:
regulation of cyclin-dependent protein kinase activity, regulation of cytokine-mediated signaling pathway, protein targeting, intracellular protein transport, protein localization, protein transport, regulation of phosphate metabolic process, cellular protein localization, regulation of phosphorylation, regulation of kinase activity, establishment of protein localization, regulation of protein kinase activity, intracellular transport, regulation of phosphorus metabolic process, regulation of transferase activity, regulation of cell cycle, regulation of interferon-gamma-mediated signaling pathway, regulation of type I interferon-mediated signaling pathway, cellular macromolecule localization,