ERBB3

Receptor tyrosine-protein kinase erbB-3 ;
Proto-oncogene-like protein c-ErbB-3 ;
Tyrosine kinase-type cell surface receptor HER3 ;

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.,disease:Overexpressed in a subset of human mammary tumors.,domain:The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.,function:Binds and is activated by neuregulins and NTAK.,PTM:Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5, PA2G4 and MUC1.,tissue specificity:Epithelial tissues and brain.,

cell morphogenesis, cell morphogenesis involved in differentiation, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, apoptosis, negative regulation of cell adhesion, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, intracellular signaling cascade, protein kinase cascade, axonogenesis, peripheral nervous system development, sensory organ development, heart development, muscle organ development, skeletal muscle tissue development, circadian rhythm, cell death, response to wounding, response to endogenous stimulus,response to hormone stimulus, positive regulation of signal transduction, negative regulation of signal transduction,glial cell differentiation, response to organic substance, regulation of protein kinase cascade, positive regulation of cell communication, negative regulation of cell communication, positive regulation of protein kinase cascade, regulation of glucose transport, positive regulation of glucose transport, regulation of cell death, programmed cell death, Schwann cell differentiation, phosphoinositide 3-kinase cascade, regulation of phosphoinositide 3-kinase cascade, positive regulation of phosphoinositide 3-kinase cascade, striated muscle tissue development, death, phosphorylation,peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, cranial nerve development, nerve development,gland morphogenesis, cell projection organization, regulation of cell adhesion, neuron differentiation, mammary gland development, neuron projection development, response to insulin stimulus, cellular response to insulin stimulus,cellular response to hormone stimulus, cellular component morphogenesis, cell part morphogenesis, wound healing,gliogenesis, regulation of cell proliferation, odontogenesis, response to drug, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, response to peptide hormone stimulus, regulation of neuron apoptosis, negative regulation of neuron apoptosis, tongue development, regulation of glucose import, positive regulation of glucose import, rhythmic process, neuron development, cell morphogenesis involved in neuron differentiation, gland development, tissue remodeling, neuron projection morphogenesis, cell projection morphogenesis, regulation of secretion, negative regulation of secretion,positive regulation of transport, negative regulation of transport, neuron apoptosis, mammary gland involution,mammary gland morphogenesis, muscle tissue development, skeletal muscle organ development, negative regulation of cell death,

[Isoform 1]: Cell membrane ; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

Epithelial tissues and brain.