GRIA4

Glutamate receptor 4 ;
GluR-4 ;
GluR4 ;
AMPA-selective glutamate receptor 4 ;
GluR-D ;
Glutamate receptor ionotropic, AMPA 4 ;
GluA4 ;

function:Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.,miscellaneous:The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.,PTM:Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with EPB41L1 via its C-terminus.,

ion transport, cell surface receptor linked signal transduction, glutamate signaling pathway, cell-cell signaling, synaptic transmission, positive regulation of cell communication, transmission of nerve impulse, regulation of neurological system process, positive regulation of neurological system process, regulation of system process, regulation of synaptic transmission, positive regulation of synaptic transmission, neurological system process, positive regulation of multicellular organismal process, regulation of synaptic transmission, glutamatergic, positive regulation of synaptic transmission, glutamatergic, regulation of transmission of nerve impulse, positive regulation of transmission of nerve impulse,

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression. .