CCNH

Cyclin-H ;
MO15-associated protein ;
p34 ;
p37 ;

function:Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin C subfamily.,subunit:Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.,

nucleotide-excision repair, DNA damage removal, DNA metabolic process, DNA repair, nucleotide-excision repair, DNA catabolic process, transcription, transcription, DNA-dependent, transcription initiation, RNA elongation, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, transcription initiation from RNA polymerase II promoter, RNA elongation from RNA polymerase II promoter, protein complex assembly, response to DNA damage stimulus, cell cycle, macromolecule catabolic process, positive regulation of biosynthetic process, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, positive regulation of cellular biosynthetic process, RNA biosynthetic process, cellular response to stress, macromolecular complex subunit organization, cellular macromolecule catabolic process, regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter,positive regulation of nitrogen compound metabolic process, regulation of RNA metabolic process, positive regulation of RNA metabolic process, macromolecular complex assembly, protein complex biogenesis,

Nucleus.