F3

Tissue factor ;
TF ;
Coagulation factor III ;
Thromboplastin ;
CD antigen CD142 ;

function:Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.,induction:TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.,online information:The Singapore human mutation and polymorphism database,online information:Tissue factor entry,similarity:Belongs to the tissue factor family.,

regulation of endothelial cell proliferation, positive regulation of endothelial cell proliferation, acute inflammatory response, activation of plasma proteins involved in acute inflammatory response, activation of blood coagulation via clotting cascade, proteolysis, apoptosis, anti-apoptosis, activation of caspase activity, defense response, inflammatory response, blood coagulation, blood coagulation, extrinsic pathway, hemostasis, cell death, positive regulation of cell proliferation, response to wounding, positive regulation of signal transduction, regulation of protein kinase cascade,regulation of platelet-derived growth factor receptor signaling pathway, positive regulation of platelet-derived growth factor receptor signaling pathway, positive regulation of cell communication, positive regulation of protein kinase cascade, regulation of cell death, positive regulation of peptidase activity, programmed cell death, death, protein processing, regulation of blood coagulation, positive regulation of blood coagulation, regulation of cell migration,positive regulation of cell migration, regulation of response to external stimulus, positive regulation of response to external stimulus, regulation of locomotion, positive regulation of locomotion, wound healing, regulation of cell proliferation, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, positive regulation of caspase activity,regulation of caspase activity, positive regulation of molecular function, regulation of angiogenesis, positive regulation of angiogenesis, positive regulation of behavior, positive regulation of response to stimulus, regulation of behavior,coagulation, regulation of coagulation, positive regulation of coagulation, regulation of body fluid levels, regulation of chemotaxis, positive regulation of chemotaxis, regulation of positive chemotaxis, positive regulation of positive chemotaxis, positive regulation of developmental process, positive regulation of multicellular organismal process,regulation of cell motion, positive regulation of cell motion, regulation of hydrolase activity, positive regulation of hydrolase activity, protein maturation, protein maturation by peptide bond cleavage, regulation of protein kinase B signaling cascade, positive regulation of protein kinase B signaling cascade, regulation of peptidase activity, regulation of endopeptidase activity, negative regulation of cell death,

[Isoform 1]: Membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

Lung, placenta and pancreas.