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PTP1B (Phospho Ser50) Cell-Based Colorimetric ELISA Kit

-KA1416C

Catalog: KA1416C
Size
Price
Status
Qty.
96well
$470.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Phospho

Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
PTPN1
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Other Name:
Tyrosine-protein phosphatase non-receptor type 1 ;
Protein-tyrosine phosphatase 1B ;
PTP-1B ;
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Database Link:
Organism Gene ID SwissProt
Human 5770; P18031;
Mouse P35821;
Rat P20417;
Background:
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:May play an important role in CKII- and p60c-src-induced signal transduction cascades.,PTM:Oxidized on Cys-215; the Cys-SOH formed in response to redox signaling reacts with the alpha-amido of the following residue to form a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity. The active site can be restored by reduction.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,
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Function:
protein amino acid dephosphorylation, phosphorus metabolic process, phosphate metabolic process, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, insulin receptor signaling pathway, response to endogenous stimulus,response to hormone stimulus, negative regulation of signal transduction, response to organic substance, negative regulation of cell communication, dephosphorylation, response to insulin stimulus, cellular response to insulin stimulus,cellular response to hormone stimulus, response to peptide hormone stimulus, regulation of insulin receptor signaling pathway, negative regulation of insulin receptor signaling pathway, negative regulation of response to stimulus,
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Cellular Localization:
Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Interacts with EPHA3 at the cell membrane.
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Tissue Expression:
Expressed in keratinocytes (at protein level).
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Catalog: KA1416C
Size
Price
Status
Qty.
96well
$470.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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