MAPK14

Mitogen-activated protein kinase 14 ;
MAP kinase 14 ;
MAPK 14 ;
Cytokine suppressive anti-inflammatory drug-binding protein ;
CSAID-binding protein ;
CSBP ;
MAP kinase MXI2 ;
MAX-interacting protein 2 ;
Mitogen-activated protein kinase p38 alpha ;
MAP kinase p38 alpha ;
Stress-activated protein kinase 2a ;
SAPK2a ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,domain:The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.,enzyme regulation:Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K3 or MAP2K6, and potentially also MAP2K4. Inhibited by dual specificity phosphatases, such as DUSP1. Specifically inhibited by the binding of pyridinyl-imidazole compounds, which are cytokine-suppressive anti-inflammatory drugs (CSAID). Isoform Mxi2 is 100-fold less sensitive to these agents than the other isoforms and is not inhibited by DUSP1. Isoform Exip is not activated by MAP2K6.,function:Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.,online information:P38 mitogen-activated protein kinases entry,PTM:Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR. This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation. Interacts with SPAG9 (By similarity). Interacts with NP60 and FAM48A.,tissue specificity:Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.,

cell cycle checkpoint, DNA damage checkpoint, skeletal system development, angiogenesis, blood vessel development,vasculature development, chondrocyte differentiation, response to molecule of bacterial origin, monosaccharide metabolic process, glucose metabolic process, regulation of transcription, DNA-dependent, regulation of transcription from RNA polymerase II promoter, protein amino acid phosphorylation, fatty acid metabolic process, phosphorus metabolic process, phosphate metabolic process, cell motion, chemotaxis, response to DNA damage stimulus, cell surface receptor linked signal transduction, intracellular signaling cascade, protein kinase cascade, small GTPase mediated signal transduction, Ras protein signal transduction, muscle organ development, skeletal muscle tissue development, behavior, locomotory behavior, response to bacterium, positive regulation of biosynthetic process,response to organic substance, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, positive regulation of gene expression, striated muscle tissue development,phosphorylation, hexose metabolic process, fatty acid oxidation, lipid modification, positive regulation of cellular biosynthetic process, DNA integrity checkpoint, lipopolysaccharide-mediated signaling pathway, response to peptidoglycan, response to muramyl dipeptide, response to lipopolysaccharide, regulation of homeostatic process,cellular response to stress, lipid oxidation, taxis, DNA damage response, signal transduction, regulation of transcription, positive regulation of cell differentiation, regulation of myeloid cell differentiation, positive regulation of myeloid cell differentiation, regulation of erythrocyte differentiation, positive regulation of erythrocyte differentiation,positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, blood vessel morphogenesis, positive regulation of developmental process, positive regulation of nitrogen compound metabolic process, cartilage development, regulation of RNA metabolic process,positive regulation of RNA metabolic process, regulation of cell cycle, muscle tissue development, skeletal muscle organ development,

Cytoplasm . Nucleus .

Brain, heart, placenta, pancreas and skeletal muscle. Expressed to a lesser extent in lung, liver and kidney.