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BLNK (Phospho Tyr96) Cell-Based Colorimetric ELISA Kit

-KA1357C

Catalog: KA1357C
Size
Price
Status
Qty.
96well
$470.00
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Main Information
Reactivity

Human, Mouse

Applications

ELISA

Conjugate/Modification


Phospho

Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
BLNK
show all
Other Name:
B-cell linker protein ;
B-cell adapter containing a SH2 domain protein ;
B-cell adapter containing a Src homology 2 domain protein ;
Cytoplasmic adapter protein ;
Src homology 2 domain-containing leukocyte protein of 65 kDa ;
SLP-65 ;
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Database Link:
Organism Gene ID SwissProt
Human 29760; Q8WV28;
Mouse Q9QUN3;
Background:
disease:Defects in BLNK are the cause of hypoglobulinemia and absent B-cells [MIM:604515]. This is a developmental blockage at the pro- to pre-B-cell transition.,disease:In 6 of 34 childhood pre-B acute lymphoblastic leukemia (ALL) samples that were tested showed a complete loss or drastic reduction of BLNK expression.,function:Functions as a central linker protein that bridges kinases associated with the B-cell receptor (BCR) with a multitude of signaling pathways, regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition (By similarity). Plays an important role in BCR-induced B-cell apoptosis.,online information:BLNK mutation db,PTM:Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways.,similarity:Contains 1 SH2 domain.,subcellular location:BCR activation results in the translocation to membrane fraction.,subunit:Associates with PLCG1, VAV1 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with VAV3, PLCG2 and GRB2. Interacts through its SH2 domain with CD79A.,tissue specificity:Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.,
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Function:
cell activation, immune system development, leukocyte differentiation, defense response, inflammatory response,immune response, humoral immune response, intracellular signaling cascade, response to wounding, hemopoiesis,lymphocyte differentiation, B cell differentiation, B cell activation, leukocyte activation, lymphocyte activation,hemopoietic or lymphoid organ development,
show all
Cellular Localization:
Cytoplasm . Cell membrane . BCR activation results in the translocation to membrane fraction.
show all
Tissue Expression:
Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
show all
Catalog: KA1357C
Size
Price
Status
Qty.
96well
$470.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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