ACLY

ATP-citrate synthase ;
ATP-citrate ;
pro-S- ;
-lyase ;
ACL ;
Citrate cleavage enzyme ;

catalytic activity:ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.,function:ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.,similarity:In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.,similarity:In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.,subunit:Homotetramer.,

citrate metabolic process, purine nucleotide metabolic process, purine nucleotide catabolic process, ATP catabolic process, coenzyme metabolic process, lipid biosynthetic process, nucleoside metabolic process, ribonucleoside metabolic process, nucleoside triphosphate metabolic process, nucleoside triphosphate catabolic process, purine nucleoside triphosphate metabolic process, purine nucleoside triphosphate catabolic process, purine ribonucleotide metabolic process, purine ribonucleotide catabolic process, nucleotide catabolic process, ribonucleoside triphosphate metabolic process, ribonucleoside triphosphate catabolic process, purine ribonucleoside triphosphate metabolic process, purine ribonucleoside triphosphate catabolic process, ribonucleotide metabolic process, ribonucleotide catabolic process, coenzyme A metabolic process, nucleoside bisphosphate metabolic process, nucleobase, nucleoside, nucleotide and nucleic acid catabolic process, nucleobase, nucleoside and nucleotide catabolic process,purine nucleoside metabolic process, nitrogen compound catabolic process, ATP metabolic process, purine ribonucleoside metabolic process, heterocycle catabolic process, cofactor metabolic process,

Cytoplasm, cytosol .