GRIN2B

Glutamate [NMDA] receptor subunit epsilon-2 ;
N-methyl D-aspartate receptor subtype 2B ;
NMDAR2B ;
NR2B ;
N-methyl-D-aspartate receptor subunit 3 ;
NR3 ;
hNR3 ;

function:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4. Interacts with HIP1 (By similarity). Interacts with MAGI3.,tissue specificity:Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.,

regulation of action potential, behavioral fear response, in utero embryonic development, startle response, suckling behavior, behavioral defense response, ion transport, cation transport, calcium ion transport, cellular ion homeostasis,defense response, cell surface receptor linked signal transduction, glutamate signaling pathway, cell-cell signaling,synaptic transmission, sensory organ development, sensory perception, behavior, learning or memory, learning,memory, feeding behavior, associative learning, detection of external stimulus, detection of abiotic stimulus, response to mechanical stimulus, response to abiotic stimulus, embryonic development ending in birth or egg hatching,response to organic substance, regulation of protein kinase cascade, regulation of glutamate secretion, positive regulation of glutamate secretion, di-, tri-valent inorganic cation transport, transmission of nerve impulse, sensory perception of pain, cellular homeostasis, metal ion transport, regulation of neurological system process, multicellular organismal response to stress, ionotropic glutamate receptor signaling pathway, regulation of membrane potential,homeostatic process, fear response, chordate embryonic development, regulation of MAPKKK cascade, regulation of system process, response to ethanol, regulation of synaptic plasticity, regulation of neuronal synaptic plasticity,regulation of long-term neuronal synaptic plasticity, response to pain, behavioral response to pain, rhythmic process,chemical homeostasis, ion homeostasis, regulation of synaptic transmission, neurological system process, cognition,neuromuscular process, detection of stimulus involved in sensory perception, sensory perception of mechanical stimulus, detection of mechanical stimulus involved in sensory perception of pain, detection of mechanical stimulus involved in sensory perception, detection of mechanical stimulus, regulation of secretion, positive regulation of secretion, positive regulation of transport, detection of stimulus, behavioral interaction between organisms,membrane depolarization, regulation of transmission of nerve impulse, cellular chemical homeostasis, regulation of postsynaptic membrane potential, regulation of excitatory postsynaptic membrane potential, regulation of cellular localization,

Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Late endosome . Lysosome . Cytoplasm, cytoskeleton . Co-localizes with the motor protein KIF17 along microtubules. .

Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.