Catalog: KA1305C
Size
Price
Status
Qty.
96well
$470.00
In stock
0
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Collected
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Main Information
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
Related Products
Primary Antibodies
MYPT1 Rabbit pAb
YT2955
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Primary Antibodies
MYPT1 (Phospho Thr696) Rabbit pAb
YP1131
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Primary Antibodies
MYPT1 (Phospho Thr853) Rabbit pAb
YP0662
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ELISA Kits
Total MYPT1 Cell-Based Colorimetric ELISA Kit
KA4192C
More→
ELISA Kits
MYPT1 (Phospho Thr853) Cell-Based Colorimetric ELISA Kit
KA1305C
More→
Antigen&Target Information
Gene Name:
PPP1R12A
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Other Name:
Protein phosphatase 1 regulatory subunit 12A ;
Myosin phosphatase-targeting subunit 1 ;
Myosin phosphatase target subunit 1 ;
Protein phosphatase myosin-binding subunit ;
Myosin phosphatase-targeting subunit 1 ;
Myosin phosphatase target subunit 1 ;
Protein phosphatase myosin-binding subunit ;
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Background:
function:Regulates myosin phosphatase activity.,PTM:Phosphorylated by CIT (Rho-associated kinase) (By similarity). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Contains 6 ANK repeats.,subcellular location:Along actomyosin filaments and stress fibers.,subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12A mediates binding to myosin. Interacts with ARHA and CIT (By similarity). Binds PPP1R12B, ROCK1 and IL16.,
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Cellular Localization:
Cytoplasm . Cytoplasm, cytoskeleton, stress fiber . Also along actomyosin filaments. .
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Tissue Expression:
Expressed in striated muscles, specifically in type 2a fibers (at protein level).
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Signaling Pathway
Cellular Processes >> Cellular community - eukaryotes >> Focal adhesion
Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton
Organismal Systems >> Immune system >> Platelet activation
Organismal Systems >> Endocrine system >> Oxytocin signaling pathway
Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction
Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway
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Catalog: KA1305C
Size
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Status
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96well
$470.00
In stock
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Collected
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