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CD3 ζ (Phospho Tyr142) Cell-Based Colorimetric ELISA Kit

-KA1275C

Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Phospho

Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
CD247
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Other Name:
T-cell surface glycoprotein CD3 zeta chain ;
T-cell receptor T3 zeta chain ;
CD antigen CD247 ;
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Database Link:
Organism Gene ID SwissProt
Human 919; P20963;
Mouse P24161;
Background:
disease:Defects in CD247 are a cause of primary T-cell immunodeficiency [MIM:610163]. Affected individuals suffer of recurrent infections. Patients T-cell counts are very low and B-cell counts are normal.,domain:The ITAM domains mediate interaction with SHB.,function:Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.,online information:CD247 mutation db,PTM:Phosphorylated on Tyr residues after T-cell receptor triggering.,similarity:Belongs to the CD3Z/FCER1G family.,similarity:Contains 3 ITAM domains.,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. CD3-zeta forms either homodimers or heterodimers with CD3-eta. Interacts with SLA and SLA2. Interacts with DOCK2 and TRAT1. Interacts with HIV-1 Nef protein. Interacts with SHB.,
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Function:
activation of immune response, immune response-activating cell surface receptor signaling pathway, positive regulation of immune system process, immune response-activating signal transduction, immune response-regulating signal transduction, immune response-regulating cell surface receptor signaling pathway, cell surface receptor linked signal transduction, positive regulation of response to stimulus, positive regulation of immune response, antigen receptor-mediated signaling pathway, T cell receptor signaling pathway,
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Cellular Localization:
Cell membrane ; Single-pass type I membrane protein.
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Tissue Expression:
CD3Z is expressed in normal lymphoid tissue and in peripheral blood mononuclear cells (PBMCs) (PubMed:11722641).
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Catalog: KA1275C
Size
Price
Status
Qty.
96well
$470.00
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