Catalog: KA1267C
Size
Price
Status
Qty.
96well
$470.00
In stock
0
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Main Information
Target
Akt1 S1
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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Primary Antibodies
PRAS40 Rabbit pAb
YT3850
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Primary Antibodies
PRAS40 (Phospho Thr246) Rabbit pAb
YP0302
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ELISA Kits
Total PRAS40 Cell-Based Colorimetric ELISA Kit
KA3016C
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ELISA Kits
Akt1 S1 (Phospho Thr246) Cell-Based Colorimetric ELISA Kit
KA1267C
More→
Antigen&Target Information
Gene Name:
AKT1S1;PRAS40
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Protein Name:
Proline-rich AKT1 substrate 1;40 kDa proline-rich AKT substrate;
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Background:
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]
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Function:
Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (By similarity).In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (By similarity).In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (By similarity).Its activity is dependent on its phosphorylation state and binding to 14-3-3 (By similarity).May also play a role in nerve growth factor-mediated neuroprotection (PubMed:14973226, PubMed:16397181).
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Cellular Localization:
Cytoplasm > cytosol. Found in the cytosolic fraction of the brain.
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Tissue Expression:
Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A-549 and HeLa) than in normal cell lines (e.g. HEK293).
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Organismal Systems >> Aging >> Longevity regulating pathway
Organismal Systems >> Aging >> Longevity regulating pathway - multiple species
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
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Catalog: KA1267C
Size
Price
Status
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96well
$470.00
In stock
0
Add to cart
Collected
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