Catalog: KA1267C
Size
Price
Status
Qty.
96well
$470.00
In stock
0
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Main Information
Target
PRAS40
Reactivity
Human, Mouse, Rat
Applications
ELISA
Conjugate/Modification
Phospho
Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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PRAS40 Rabbit pAb
YT3850
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Primary Antibodies
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YP0302
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ELISA Kits
Total PRAS40 Cell-Based Colorimetric ELISA Kit
KA3016C
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ELISA Kits
Akt1 S1 (Phospho Thr246) Cell-Based Colorimetric ELISA Kit
KA1267C
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Antigen&Target Information
Gene Name:
AKT1S1 PRAS40
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Protein Name:
Proline-rich AKT1 substrate 1;40 kDa proline-rich AKT substrate;
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Other Name:
AKT1S1 ;
PRAS40 ;
Proline-rich AKT1 substrate 1 ;
40 kDa proline-rich AKT substrate
PRAS40 ;
Proline-rich AKT1 substrate 1 ;
40 kDa proline-rich AKT substrate
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Background:
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008],
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Function:
Function:May play an important role in phosphatidylinositol 3-kinase (PI3K)-AKT1 survival signaling. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. May also play a role in nerve growth factor-mediated neuroprotection.,subcellular location:Found in the cytosolic fraction of the brain.,subunit:The phosphorylated form interacts with 14-3-3.,tissue specificity:Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A549 and HeLa) than in normal cell lines (e.g. HEK293).,
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Cellular Localization:
Cytoplasm > cytosol. Found in the cytosolic fraction of the brain.
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Tissue Expression:
Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A-549 and HeLa) than in normal cell lines (e.g. HEK293).
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Organismal Systems >> Aging >> Longevity regulating pathway
Organismal Systems >> Aging >> Longevity regulating pathway - multiple species
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
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Catalog: KA1267C
Size
Price
Status
Qty.
96well
$470.00
In stock
0
Add to cart
Collected
Collect
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