FADD

Protein FADD ;
FAS-associated death domain protein ;
FAS-associating death domain-containing protein ;
Growth-inhibiting gene 3 protein ;
Mediator of receptor induced toxicity ;

domain:Contains a death domain involved in the binding of the corresponding domain within Fas receptor.,function:Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.,PTM:Phosphorylated.,similarity:Contains 1 death domain.,similarity:Contains 1 DED (death effector) domain.,subunit:Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD.,tissue specificity:Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.,

protein complex assembly, apoptosis, induction of apoptosis, cell death, induction of apoptosis by extracellular signals,activation of pro-apoptotic gene products, positive regulation of signal transduction, regulation of protein kinase cascade, positive regulation of cell communication, positive regulation of protein kinase cascade, regulation of cell death, positive regulation of cell death, programmed cell death, induction of programmed cell death, death, regulation of apoptosis, positive regulation of apoptosis, regulation of programmed cell death, positive regulation of programmed cell death, regulation of I-kappaB kinase/NF-kappaB cascade, positive regulation of I-kappaB kinase/NF-kappaB cascade, macromolecular complex subunit organization, protein oligomerization, protein heterooligomerization,macromolecular complex assembly, necrotic cell death, protein complex biogenesis,

Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.