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PLCG1 (Phospho Tyr783) Cell-Based Colorimetric ELISA Kit

-KA1214C

Catalog: KA1214C
Size
Price
Status
Qty.
96well
$470.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Phospho

Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
PLCG1
show all
Other Name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 ;
PLC-148 ;
Phosphoinositide phospholipase C-gamma-1 ;
Phospholipase C-II ;
PLC-II ;
Phospholipase C-gamma-1 ;
PLC-gamma-1 ;
show all
Database Link:
Organism Gene ID SwissProt
Human 5335; P19174;
Mouse Q62077;
Rat P10686;
Background:
catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,domain:The SH3 domain mediates interaction with CLNK (By similarity). The SH3 domain also mediates interaction with RALGPS1.,function:PLC-gamma is a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.,PTM:The receptor-mediated activation of PLC-gamma-1 and PLC-gamma-2 involves their phosphorylation by tyrosine kinases in response to ligation of a variety of growth factor receptors and immune system receptors.,PTM:Ubiquitinated by CBLB in activated T-cells.,similarity:Contains 1 C2 domain.,similarity:Contains 1 EF-hand domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 PH domains.,similarity:Contains 2 SH2 domains.,similarity:Contains 3 PH domains.,subunit:Interacts with AGAP2 via its SH3 domain (By similarity). Interacts with phosphorylated LAT upon TCR activation. Interacts with the Pro-rich domain of TNK1 via its SH3 domain. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts via its SH3 domain with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1 and CLNK (By similarity). Interacts with RALGPS1. Interacts (via SH3 domain) with HEV ORF3 protein.,
show all
Function:
in utero embryonic development, phospholipid metabolic process, intracellular signaling cascade, phospholipid catabolic process, embryonic development ending in birth or egg hatching, lipid catabolic process, organophosphate metabolic process, chordate embryonic development, cellular lipid catabolic process,
show all
Cellular Localization:
Cell projection, lamellipodium . Cell projection, ruffle . Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment. .
show all
Signaling Pathway
Organismal Systems >> Immune system >> Neutrophil extracellular trap formation Organismal Systems >> Immune system >> Natural killer cell mediated cytotoxicity Organismal Systems >> Immune system >> T cell receptor signaling pathway Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation Organismal Systems >> Immune system >> Th17 cell differentiation Organismal Systems >> Immune system >> Fc epsilon RI signaling pathway Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis Organismal Systems >> Immune system >> Leukocyte transendothelial migration Organismal Systems >> Immune system >> Chemokine signaling pathway Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway Organismal Systems >> Nervous system >> Neurotrophin signaling pathway Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels Human Diseases >> Cancer: overview >> Pathways in cancer Human Diseases >> Cancer: overview >> MicroRNAs in cancer Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma Human Diseases >> Cancer: specific types >> Glioma Human Diseases >> Cancer: specific types >> Non-small cell lung cancer Human Diseases >> Neurodegenerative disease >> Parkinson disease Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases Environmental Information Processing >> Signal transduction >> ErbB signaling pathway Environmental Information Processing >> Signal transduction >> Ras signaling pathway Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway Environmental Information Processing >> Signal transduction >> VEGF signaling pathway Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway Environmental Information Processing >> Signal transduction >> HIF-1 signaling pathway Environmental Information Processing >> Signal transduction >> Calcium signaling pathway Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway
Catalog: KA1214C
Size
Price
Status
Qty.
96well
$470.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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