PRKCZ

Protein kinase C zeta type ;
nPKC-zeta ;

catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The C1 domain does not bind the diacylglycerol (DAG).,domain:The OPR domain mediates mutually exclusive interactions with SQSTM1 and PARD6B.,enzyme regulation:Phosphatidylinositol 3,4,5-trisphosphate might be a physiological activator. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn motif), need to be phosphorylated for its full activation.,function:PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization.,function:This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 OPR domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,subcellular location:In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes.,subunit:Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3. Forms a complex with SQSTM1 and MAP2K5 (By similarity). Interacts with PARD6A, PARD6B, PARD6G and SQSTM1. Part of a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with ADAP1/CENTA1. Forms a ternary complex composed of SQSTM1 and PAWR. Interacts directly with SQSTM1 (Probable). Interacts with IKBKB.,tissue specificity:Expressed in brain, and to a lesser extent in lung, kidney and testis.,

microtubule cytoskeleton organization, regulation of protein amino acid phosphorylation, negative regulation of protein amino acid phosphorylation, regulation of cell-matrix adhesion, positive regulation of cell-matrix adhesion,protein complex assembly, protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, cellular ion homeostasis, anti-apoptosis, cytoskeleton organization, microtubule-based process, microtubule-based movement, cell surface receptor linked signal transduction, intracellular signaling cascade, behavior, learning or memory, memory, long-term memory, positive regulation of cell proliferation, negative regulation of signal transduction, regulation of phospholipase activity, positive regulation of phospholipase activity, negative regulation of phosphorus metabolic process, negative regulation of macromolecule metabolic process, positive regulation of cell communication, negative regulation of cell communication, regulation of cell-substrate adhesion, positive regulation of cell-substrate adhesion, regulation of glucose transport, positive regulation of glucose transport, regulation of cell death, microtubule-based transport, phosphorylation, peptidyl-serine phosphorylation, peptidyl-serine modification,regulation of phosphate metabolic process, cellular homeostasis, actin filament-based process, actin cytoskeleton organization, regulation of cell adhesion, cytoskeleton-dependent intracellular transport, negative regulation of protein complex assembly, regulation of protein modification process, negative regulation of protein modification process, actin cytoskeleton reorganization, activation of phospholipase D activity, regulation of neurological system process, positive regulation of neurological system process, activation of protein kinase activity, activation of protein kinase B activity, regulation of cellular protein metabolic process, negative regulation of cellular protein metabolic process, regulation of protein localization, positive regulation of kinase activity, regulation of cell proliferation,regulation of phosphorylation, negative regulation of phosphorylation, regulation of membrane potential, homeostatic process, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, positive regulation of catalytic activity, negative regulation of catalytic activity,regulation of protein complex assembly, regulation of kinase activity, macromolecular complex subunit organization,regulation of system process, regulation of cellular component biogenesis, negative regulation of molecular function,positive regulation of molecular function, positive regulation of cell adhesion, regulation of protein kinase activity,positive regulation of protein kinase activity, negative regulation of phosphate metabolic process, regulation of glucose import, positive regulation of glucose import, regulation of insulin receptor signaling pathway, negative regulation of insulin receptor signaling pathway, intracellular transport, vesicle transport along microtubule, negative regulation of response to stimulus, chemical homeostasis, regulation of peptidyl-tyrosine phosphorylation, negative regulation of peptidyl-tyrosine phosphorylation, ion homeostasis, regulation of synaptic transmission, positive regulation of synaptic transmission, neurological system process, cognition, positive regulation of transport, negative regulation of cellular component organization, regulation of phosphorus metabolic process, positive regulation of protein transport, regulation of protein transport, positive regulation of multicellular organismal process, negative regulation of protein metabolic process, protein oligomerization, protein heterooligomerization, regulation of hydrolase activity, regulation of transferase activity, positive regulation of hydrolase activity, negative regulation of hydrolase activity, positive regulation of transferase activity, membrane depolarization, regulation of transmission of nerve impulse, positive regulation of transmission of nerve impulse, cellular chemical homeostasis, membrane hyperpolarization, regulation of lipase activity, positive regulation of lipase activity, negative regulation of cell death,macromolecular complex assembly, regulation of establishment of protein localization, protein complex biogenesis,

Cytoplasm . Endosome . Cell junction . Membrane ; Peripheral membrane protein . In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes (PubMed:9566925). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (PubMed:7597083). Colocalizes with VAMP2 and WDFY2 in intracellular vesicles (PubMed:17313651). Transiently translocates to the membrane of CA1 hippocampal cells in response to the induction of long term potentiation (By similarity). .; [Isoform 2]: Cytoplasm .

Expressed in brain, and to a lesser extent in lung, kidney and testis.