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Keratin 18 (Phospho Ser33) Cell-Based Colorimetric ELISA Kit

-KA1172C

Catalog: KA1172C
Size
Price
Status
Qty.
96well
$470.00
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Main Information
Reactivity

Human, Mouse, Rat

Applications

ELISA

Conjugate/Modification


Phospho

Detailed Information
Storage
2-8°C/6 months
Modification
Phospho
Detection Method
Colorimetric
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Antigen&Target Information
Gene Name:
KRT18
show all
Other Name:
Keratin, type I cytoskeletal 18 ;
Cell proliferation-inducing gene 46 protein ;
Cytokeratin-18 ;
CK-18 ;
Keratin-18 ;
K18 ;
show all
Database Link:
Organism Gene ID SwissProt
Human 3875; P05783;
Mouse P05784;
Rat Q5BJY9;
Background:
disease:Defects in KRT18 are a cause of cryptogenic cirrhosis [MIM:215600].,function:Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.,induction:By IL-6.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues.,PTM:Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.,PTM:Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8. Interacts with the thrombin-antithrombin complex (By similarity). Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD.,tissue specificity:Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.,
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Function:
intracellular protein transport, post-Golgi vesicle-mediated transport, Golgi to plasma membrane transport, apoptosis,cell cycle, protein localization, cell death, regulation of cell death, programmed cell death, protein transport, vesicle-mediated transport, death, cytokine-mediated signaling pathway, tumor necrosis factor-mediated signaling pathway,cellular protein localization, regulation of apoptosis, Golgi to plasma membrane CFTR protein transport, Golgi to plasma membrane protein transport, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, establishment of protein localization, intracellular transport, Golgi vesicle transport, negative regulation of cell death, cellular macromolecule localization,
show all
Cellular Localization:
Cytoplasm, perinuclear region. Nucleus, nucleolus.
show all
Tissue Expression:
Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
show all
Catalog: KA1172C
Size
Price
Status
Qty.
96well
$470.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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