EFNB1/EFNB2

disease:Defects in EFNB1 are a cause of craniofrontonasal syndrome (CFNS) [MIM:304110]; also known as craniofrontonasal dysplasia (CFND). CFNS is an X-linked inherited syndrome characterized by hypertelorism, coronal synostosis with brachycephaly, downslanting palpebral fissures, clefting of the nasal tip, joint anomalies, longitudinally grooved fingernails and other digital anomalies.,function:Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.,induction:By TNF-alpha.,PTM:Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.,similarity:Belongs to the ephrin family.,subunit:Interacts with GRIP1 and GRIP2.,tissue specificity:Heart, placenta, lung, liver, skeletal muscle, kidney, pancreas.,

cell morphogenesis, cell morphogenesis involved in differentiation, ameboidal cell migration, neural crest cell migration,positive regulation of immune system process, regulation of leukocyte activation, positive regulation of leukocyte activation, cell motion, cell adhesion, cell-cell signaling, pattern specification process, axonogenesis, axon guidance,positive regulation of cell proliferation, embryonic pattern specification, mesenchymal cell development, neural crest cell development, neural crest cell differentiation, cell migration, biological adhesion, cell projection organization,neuron differentiation, neuron projection development, regulation of mononuclear cell proliferation, positive regulation of mononuclear cell proliferation, cellular component morphogenesis, cell part morphogenesis, positive regulation of T cell proliferation, regulation of cell proliferation, regulation of T cell proliferation, neuron development, cell morphogenesis involved in neuron differentiation, mesenchymal cell differentiation, neuron projection morphogenesis,cell projection morphogenesis, cell motility, regulation of lymphocyte proliferation, positive regulation of lymphocyte proliferation, regulation of T cell activation, regulation of cell activation, positive regulation of cell activation, positive regulation of T cell activation, regulation of lymphocyte activation, positive regulation of lymphocyte activation,localization of cell, mesenchyme development, regulation of leukocyte proliferation, positive regulation of leukocyte proliferation,

Cell membrane ; Single-pass type I membrane protein . Membrane raft . May recruit GRIP1 and GRIP2 to membrane raft domains. .; [Ephrin-B1 C-terminal fragment]: Cell membrane ; Single-pass type I membrane protein .; [Ephrin-B1 intracellular domain]: Nucleus . Colocalizes with ZHX2 in the nucleus. .

Widely expressed (PubMed:8070404, PubMed:7973638). Detected in both neuronal and non-neuronal tissues (PubMed:8070404, PubMed:7973638). Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638).