MTOR

Serine/threonine-protein kinase mTOR ;
FK506-binding protein 12-rapamycin complex-associated protein 1 ;
FKBP12-rapamycin complex-associated protein ;
Mammalian target of rapamycin ;
mTOR ;
Mechanistic target of rapamycin ;
Rapamycin and FKBP12 target 1 ;
Rapamycin target protein 1 ;

function:Acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Part of the TORC2 complex which plays a critical role in AKT1 Ser-473 phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.,similarity:Belongs to the PI3/PI4-kinase family.,similarity:Contains 1 FAT domain.,similarity:Contains 1 FATC domain.,similarity:Contains 1 PI3K/PI4K domain.,similarity:Contains 7 HEAT repeats.,subunit:Interacts with the FKBP12-rapamycin complex. Binds UBQLN1. Forms part of the mammalian target of rapamycin 2 complex (TORC2) comprised of FRAP1, GBL, PRR5, RICTOR and SIN. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to PRR5 and RICTOR within the TORC2 complex.,tissue specificity:Expressed in numerous tissues, with highest levels in testis.,

response to acid, regulation of protein amino acid phosphorylation, positive regulation of protein amino acid phosphorylation, regulation of endothelial cell proliferation, positive regulation of endothelial cell proliferation,reproductive developmental process, regulation of glycogen biosynthetic process, regulation of carbohydrate metabolic process, regulation of translation, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, intracellular signaling cascade, gamete generation, germ cell development, response to nutrient, regulation of actin polymerization or depolymerization, positive regulation of cell proliferation, regulation of cell size, macromolecule catabolic process, response to endogenous stimulus, response to hormone stimulus, positive regulation of biosynthetic process, regulation of catabolic process, negative regulation of catabolic process, positive regulation of signal transduction, response to extracellular stimulus, response to organic substance, response to organic nitrogen, regulation of autophagy, negative regulation of autophagy, positive regulation of macromolecule biosynthetic process, positive regulation of phosphorus metabolic process, regulation of cellular ketone metabolic process, regulation of lamellipodium assembly, positive regulation of lamellipodium assembly, positive regulation of macromolecule metabolic process, posttranscriptional regulation of gene expression, regulation of protein kinase cascade, positive regulation of organelle organization, positive regulation of cell communication, negative regulation of cell communication, regulation of cellular carbohydrate metabolic process, positive regulation of protein kinase cascade, regulation of glucose metabolic process, regulation of glucan biosynthetic process, response to amine stimulus, cell growth, regulation of macroautophagy, negative regulation of macroautophagy, phosphorylation,peptidyl-threonine phosphorylation, peptidyl-threonine modification, regulation of lipid metabolic process, regulation of fatty acid metabolic process, regulation of phosphate metabolic process, sexual reproduction, cell projection organization, protein catabolic process, regulation of actin filament length, regulation of actin filament polymerization,positive regulation of actin filament polymerization, positive regulation of cellular biosynthetic process, regulation of cellular catabolic process, negative regulation of cellular catabolic process, positive regulation of protein complex assembly, regulation of cell projection organization, positive regulation of cell projection organization, regulation of protein modification process, positive regulation of protein modification process, ruffle organization, response to nutrient levels, TOR signaling pathway, regulation of fatty acid beta-oxidation, regulation of response to food,regulation of response to external stimulus, negative regulation of response to external stimulus, regulation of response to extracellular stimulus, negative regulation of response to extracellular stimulus, regulation of response to nutrient levels, negative regulation of response to nutrient levels, regulation of actin filament bundle formation,positive regulation of actin filament bundle formation, regulation of cellular protein metabolic process, positive regulation of cellular protein metabolic process, regulation of protein polymerization, positive regulation of protein polymerization, regulation of Rac GTPase activity, regulation of Ras GTPase activity, regulation of Rho GTPase activity,multicellular organism reproduction, regulation of cellular component size, response to insulin stimulus, regulation of polysaccharide metabolic process, regulation of polysaccharide biosynthetic process, regulation of actin cytoskeleton organization, regulation of actin filament-based process, regulation of organelle organization, regulation of Rac protein signal transduction, regulation of Rho protein signal transduction, growth, regulation of cell proliferation,regulation of phosphorylation, positive regulation of phosphorylation, regulation of GTPase activity, response to amino acid stimulus, regulation of protein complex assembly, regulation of carbohydrate biosynthetic process, response to peptide hormone stimulus, regulation of generation of precursor metabolites and energy, regulation of kinase activity,regulation of carbohydrate utilization, regulation of cellular component biogenesis, positive regulation of translation,negative regulation of cell size, regulation of protein kinase activity, positive regulation of phosphate metabolic process, regulation of fatty acid oxidation, regulation of Ras protein signal transduction, protein amino acid autophosphorylation, negative regulation of response to stimulus, reproductive process in a multicellular organism,reproductive cellular process, regulation of peptidyl-tyrosine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation, regulation of lipid catabolic process, regulation of small GTPase mediated signal transduction,positive regulation of cellular component organization, regulation of phosphorus metabolic process, positive regulation of protein metabolic process, regulation of hydrolase activity, regulation of transferase activity, regulation of stress fiber formation, regulation of cytoskeleton organization, positive regulation of cytoskeleton organization, positive regulation of stress fiber formation, regulation of protein kinase B signaling cascade, positive regulation of protein kinase B signaling cascade, regulation of cell projection assembly, regulation of cellular response to stress,

Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome . Cytoplasm . Nucleus, PML body . Microsome membrane . Lysosome membrane . Cytoplasmic vesicle, phagosome . Shuttles between cytoplasm and nucleus. Accumulates in the nucleus in response to hypoxia (By similarity). Targeting to lysosomes depends on amino acid availability and RRAGA and RRAGB (PubMed:18497260, PubMed:20381137). Lysosome targeting also depends on interaction with MEAK7. Translocates to the lysosome membrane in the presence of TM4SF5 (PubMed:30956113). .

Expressed in numerous tissues, with highest levels in testis.