IGF1R

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.,enzyme regulation:Autophosphorylation activates the kinase activity.,function:This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.,online information:IGF-1 receptor entry,PTM:Phosphorylation of Tyr-980 is required for IRS1- and SHC1-binding.,PTM:The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin-like growth factor I (IGF I).,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 3 fibronectin type-III domains.,subunit:Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R.,tissue specificity:Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibrobasts, spleen and placenta (at protein level). Expressed in a variety of tissues.,

cell morphogenesis, cell morphogenesis involved in differentiation, reproductive developmental process, regulation of DNA replication, protein complex assembly, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, anti-apoptosis, immune response, establishment or maintenance of cell polarity, cell surface receptor linked signal transduction, enzyme linked receptor protein signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, intracellular signaling cascade, protein kinase cascade,axonogenesis, sex determination, positive regulation of cell proliferation, insulin receptor signaling pathway, response to endogenous stimulus, response to hormone stimulus, positive regulation of biosynthetic process, response to organic substance, positive regulation of macromolecule biosynthetic process, positive regulation of macromolecule metabolic process, regulation of cell death, phosphoinositide 3-kinase cascade, phosphorylation, second-messenger-mediated signaling, establishment of cell polarity, cell projection organization, neuron differentiation, male sex determination, regulation of cell migration, positive regulation of cell migration, mammary gland development, neuron projection development, positive regulation of cellular biosynthetic process, response to insulin stimulus, cellular response to insulin stimulus, cellular response to hormone stimulus, cellular component morphogenesis, cell part morphogenesis, regulation of locomotion, positive regulation of locomotion, regulation of cell proliferation, regulation of apoptosis, negative regulation of apoptosis, regulation of programmed cell death, negative regulation of programmed cell death, response to peptide hormone stimulus, macromolecular complex subunit organization,positive regulation of DNA replication, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, protein amino acid autophosphorylation, insulin-like growth factor receptor signaling pathway,phosphoinositide-mediated signaling, neuron development, cell morphogenesis involved in neuron differentiation,gland development, neuron projection morphogenesis, cell projection morphogenesis, regulation of DNA metabolic process, positive regulation of DNA metabolic process, positive regulation of nitrogen compound metabolic process,protein oligomerization, protein tetramerization, regulation of cell motion, positive regulation of cell motion, protein heterooligomerization, negative regulation of cell death, macromolecular complex assembly, protein complex biogenesis,

Cell membrane ; Single-pass type I membrane protein .

Found as a hybrid receptor with INSR in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta (at protein level). Expressed in a variety of tissues. Overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney.