C5AR1

C5a anaphylatoxin chemotactic receptor ;
C5a-R ;
C5aR ;
CD antigen CD88 ;

function:Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.,PTM:Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.,similarity:Belongs to the G-protein coupled receptor 1 family.,

MAPKKK cascade, activation of MAPK activity, protein amino acid phosphorylation, phosphorus metabolic process,phosphate metabolic process, cellular ion homeostasis, cellular calcium ion homeostasis, cellular metal ion homeostasis, chemotaxis, defense response, immune response, cellular defense response, cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, activation of phospholipase C activity,elevation of cytosolic calcium ion concentration, intracellular signaling cascade, protein kinase cascade, sensory perception, sensory perception of chemical stimulus, behavior, locomotory behavior, regulation of phospholipase activity, positive regulation of phospholipase activity, positive regulation of phospholipase C activity, phosphorylation,regulation of phosphate metabolic process, cellular homeostasis, cellular cation homeostasis, cellular di-, tri-valent inorganic cation homeostasis, positive regulation of kinase activity, regulation of phosphorylation, taxis, homeostatic process, positive regulation of catalytic activity, regulation of MAP kinase activity, positive regulation of MAP kinase activity, regulation of kinase activity, positive regulation of molecular function, regulation of protein kinase activity,positive regulation of protein kinase activity, chemical homeostasis, ion homeostasis, neurological system process,cognition, regulation of phosphorus metabolic process, regulation of hydrolase activity, regulation of transferase activity, positive regulation of hydrolase activity, positive regulation of transferase activity, cytosolic calcium ion homeostasis, metal ion homeostasis, di-, tri-valent inorganic cation homeostasis, calcium ion homeostasis, cation homeostasis, cellular chemical homeostasis, regulation of lipase activity, positive regulation of lipase activity,

Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle . Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. .